NHERF-1 Products

Description

EBP 50 [ERM (ezrin-radixin-moesin) binding phosphoprotein of 50 kDa] is a PDZ containing protein that is involved in the linkage of integral membrane proteins to the cytoskeleton. EBP50 contains two tandem PDZ domains followed by a carboxy-terminal sequence that binds to members of the ERM family of membrane-cytoskeleton adaptors. The PDZ domains within EBP50 bind to the carboxy termini of such target proteins as beta2 adrenergic receptor, platelet-derived growth factor receptor (PDGFR), and the cystic fibrosis conductance regulator (CFTR). The PDZ domains are also believed to be involved in the oligomerization of EBP 50 to form multiprotein complexes which helps to facilitate the formation of functional signalling complexes. EBP 50 has been shown to link integral membrane proteins to the cytoskeleton by binding to members of the ERM family of proteins, which bind to F-actin. Through these interactions, EBP 50 is implicated in the localization of interactive groups of proteins into subcellular domains and in the regulation of activity of those interacting proteins. Immunohistochemical studies have shown that EBP 50 is found exclusively at the apical membranes of epithelial cells.

Bioinformatics

Uniprot	NM_004252 Human NP_004243 Human NP_004243.1 Human O14745 Human
Product By Gene ID	9368
Alternate Names	EBP50NHERF-1 ezrin-radixin-moesin binding phosphoprotein-50 Ezrin-radixin-moesin-binding phosphoprotein 50 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Na+/H+ exchange regulatory co-factor NHERF1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 NHERFNPHLOP2 Regulatory cofactor of Na(+)/H(+) exchanger sodium/hydrogen exchanger regulatory factor 1 Sodium-hydrogen exchanger regulatory factor 1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatoryfactor 1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 Solute carrier family 9 isoform A3 regulatory factor 1

Research Areas for NHERF-1

Find related products by research area and learn more about each of the different research areas below.

Cytoskeleton Markers
Signal Transduction