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NF2/Merlin Antibody

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Immunohistochemistry: NF2/Merlin Antibody [NB100-93527] - Staining (5µg/ml) of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-Staining.

Product Details

Summary
Reactivity Hu, ZeSpecies Glossary
Applications ELISA, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

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NF2/Merlin Antibody Summary

Immunogen
Peptide with sequence C-EKSKHLQDQLK corresponding to internal region according to Uniprot Zebrafish NP_998116.1.
Epitope
C-EKSKHLQDQLK
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
NF2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
IHC-P: An anonymous customer has reported successful usage on zebrafish brain cortex.
Control
NF2/Merlin Overexpression Lysate
Publications
Read Publication using NB100-93527.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NF2/Merlin Antibody

  • ACN
  • BANF
  • Merlin
  • moesin-ezrin-radixin like
  • Moesin-ezrin-radixin-like protein
  • moesin-ezrin-radizin-like protein
  • neurofibromin 2 (bilateral acoustic neuroma)
  • neurofibromin 2 (merlin)
  • neurofibromin-2
  • NF2
  • SCH
  • Schwannomerlin
  • Schwannomin

Background

Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NF2/Merlin Antibody (NB100-93527)(1)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol NF2
Entrez
Uniprot