MYO9B Antibody

Myosin IX belongs to the family of unconventional myosins, distinct from the classical myosins I and myosins II. Myosin IX, thought to be involved in signal transduction and leukocyte differentiation, includes several isoforms. The rat isoforms are myosin IX/Myr5 (230 kDa) and Myr7 (300 kDa), and the human isoforms are myosin IXa (MYO9A) and myosin IXb (MYO9B). The isoforms of myosin IX have similar overall domain structure and are expressed in many tissues and cell types, although they have distinct tissue expression patterns. The subcellular localization of class IX myosins appears to be partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. The expression level of myosins IX may vary during development and differentiation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 2 of 2.

Publications using NB100-41092	Applications	Species
McMichael BK, Scherer KF, Franklin NC, Lee BS. The RhoGAP activity of myosin IXB is critical for osteoclast podosome patterning, motility, and resorptive capacity. PLoS ONE. 2014-01-27 [PMID: 24466350] (ICC/IF, WB, Mouse) Details: Mouse bone marrow derived osteoclasts: IF (Fig 1), WB (Fig 1A). Note: The specificity of the MYO9B pAb was validated with MYO9B siRNA and in MYO9B transfected osteoclasts by WB. a goat polyclonal Ab from Imgenex were used to detect Myo9b.	ICC/IF, WB	Mouse
Monsuur AJ, de Bakker PI, Alizadeh BZ et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005-12-01 [PMID: 16282976]

Array NB100-41092

• MYO9B Antibodies
• MYO9B Proteins