Mouse IL-15 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-15 (Interleukin 15) is a cytokine that induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells. It also induces dendritic cell differentiation and inflammatory activation, exhibits anti-tumor activity, and inhibits the deposition of lipid in adipocytes. Complexes of IL-15 with cell surface IL-15 R alpha interact with complexes of IL-2 R beta and the Common gamma Chain on adjacent cells. This transpresentation mechanism enables cells to respond to IL-15 even if they do not express IL-15 R alpha. Ligation of membrane-associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells. The activity of circulating IL-15 is limited by its association with soluble IL-15 R alpha.

We have publications tested in 2 confirmed species: Mouse, Chinese Hamster.

Showing Publications 1 - 10 of 24. Show All 24 Publications. Collapse Publications.

Publications using DY447	Applications	Species
Vile, R;Pulido, J;Chen, A;Kendall, B;Tonne, J;Metko, M;Thompson, J;Sangsuwannukul, T;Yerovi, MC;Diaz, R;Webb, M;Huff, A;Moore, M;Schuelke, M;Irshad, S;Appleton, E;Melcher, A; Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome Research square 2024-11-15 [PMID: 39606441] (Mouse)		Mouse
Gay, L;Suwan, K;Hajitou, A; Construction and utilization of a new generation of bacteriophage-based particles, or TPA, for guided systemic delivery of nucleic acids to tumors Nature protocols 2024-09-05 [PMID: 39237829] (Mouse)		Mouse
Pouxvielh, K;Marotel, M;Drouillard, A;Villard, M;Moreews, M;Bossan, A;Poiget, M;Khoryati, L;Benezech, S;Fallone, L;Hamada, S;Rousseaux, N;Picq, L;Rocca, Y;Berton, A;Teixeira, M;Mathieu, AL;Ainouze, M;Hasan, U;Fournier, A;Thaunat, O;Marçais, A;Walzer, T; Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints Science advances 2024-08-30 [PMID: 39196934] (Mouse)		Mouse
Mayall, JR;Horvat, JC;Mangan, NE;Chevalier, A;McCarthy, H;Hampsey, D;Donovan, C;Brown, AC;Matthews, AY;de Weerd, NA;de Geus, ED;Starkey, MR;Kim, RY;Daly, K;Goggins, BJ;Keely, S;Maltby, S;Baldwin, R;Foster, PS;Boyle, MJ;Tanwar, PS;Huntington, ND;Hertzog, PJ;Hansbro, PM; Interferon-epsilon is a novel regulator of NK cell responses in the uterus EMBO molecular medicine 2024-01-23 [PMID: 38263527] (Mouse)		Mouse
P Asavarut, S Waramit, K Suwan, GJK Marais, A Chongchai, S Benjathumm, M Al-Bahrani, P Vila-Gomez, M Williams, P Kongtawele, T Yata, A Hajitou Systemically targeted cancer immunotherapy and gene delivery using transmorphic particles Oncogene, 2022-06-27;0(0):e15418. 2022-06-27 [PMID: 35758207] (Mouse)		Mouse
M Gagliardi, R Monzani, N Clemente, L Fusaro, V Saverio, G Grieco, E Pa?czyszyn, N Yissachar, F Boccafosch, M Corazzari A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD) Biology, 2021-06-30;10(7):. 2021-06-30 [PMID: 34209277] (Mouse)		Mouse
E Ferrari, R Monzani, V Saverio, M Gagliardi, E Pa?czyszyn, V Raia, VR Villella, G Bona, M Pane, A Amoruso, M Corazzari Probiotics Supplements Reduce ER Stress and Gut Inflammation Associated with Gliadin Intake in a Mouse Model of Gluten Sensitivity Nutrients, 2021-04-07;13(4):. 2021-04-07 [PMID: 33917155] (Mouse)		Mouse
A Suhail, ZA Rizvi, P Mujagond, SA Ali, P Gaur, M Singh, V Ahuja, A Awasthi, CV Srikanth DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells Cell Rep, 2019-12-10;29(11):3522-3538.e7. 2019-12-10 [PMID: 31825833] (Mouse)		Mouse
M Marx, M Zumpe, S Troschke-M, D Shah, HN Lode, N Siebert Co-expression of IL-15 enhances anti-neuroblastoma effectivity of a tyrosine hydroxylase-directed DNA vaccination in mice PLoS ONE, 2018-11-19;13(11):e0207320. 2018-11-19 [PMID: 30452438] (Chinese Hamster)		Chinese Hamster
MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)		Mouse
R Riff, Y Cohen, H Eini-Rider, O Naamani, J Mazar, YS Haviv, C Chaimovitz, A Douvdevani Systemic inflammatory response syndrome-related lymphopenia is associated with adenosine A1 receptor dysfunction J. Leukoc. Biol., 2017-05-11;0(0):. 2017-05-11 [PMID: 28495790] (Mouse)		Mouse
N Sanadgol, F Golab, Z Tashakkor, N Taki, S Moradi Kou, A Mostafaie, M Mehdizadeh, M Abdollahi, G Taghizadeh, M Sharifzade Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis Pharm Biol, 2017-12-01;55(1):1679-1687. 2017-12-01 [PMID: 28447514] (Mouse)		Mouse
Michel van Gelder Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer Breast Cancer Res. Treat, 2016-12-03;0(0):. 2016-12-03 [PMID: 27915436] (Mouse)		Mouse
Bryan Simons PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen J. Immunol, 2016-11-28;0(0):. 2016-11-28 [PMID: 27895167] (Mouse)		Mouse
Marcus Maurer Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure J. Immunol., 2016-11-02;0(0):. 2016-11-02 [PMID: 27807191] (Mouse)		Mouse
Sun H, Liu D Hydrodynamic delivery of interleukin 15 gene promotes resistance to high fat diet-induced obesity, fatty liver and improves glucose homeostasis. Gene Ther, 2014-12-11;22(4):341-7. 2014-12-11 [PMID: 25503694] (Mouse)		Mouse
Nishio N, Diaconu I, Liu H, Cerullo V, Caruana I, Hoyos V, Bouchier-Hayes L, Savoldo B, Dotti G Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res, 2014-07-24;74(18):5195-205. 2014-07-24 [PMID: 25060519] (Mouse)		Mouse
Ma , Ning, Xing , Chen, Xiao , He, He , Youdi, Han , Gencheng, Chen , Guojiang, Hou , Chunmei, Marrero , Bernadet, Wang , Yujuan, Zhang , Shengqua, Shen , Beifen, Li , Yan, Wang , Renxi BAFF suppresses IL-15 expression in B cells. J Immunol, 2014-03-26;192(9):4192-201. 2014-03-26 [PMID: 24670802] (Mouse)		Mouse
Jayaraman A, Jackson D, Message S, Pearson R, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu L, Johnston S, Bartlett N IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection. Mucosal Immunol, 2014-01-29;7(5):1151-64. 2014-01-29 [PMID: 24472849] (Mouse)		Mouse
Ueda R, Fujita M, Zhu X, Sasaki K, Kastenhuber ER, Kohanbash G, McDonald HA, Harper J, Lonning S, Okada H Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines. Clin. Cancer Res., 2009-10-27;15(21):6551-9. 2009-10-27 [PMID: 19861464] (Mouse)		Mouse
Yang CH, Tian L, Ling GS, Trendell-Smith NJ, Ma L, Lo CK, Stott DI, Liew FY, Huang FP Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. Eur. J. Immunol., 2008-06-01;38(6):1664-76. 2008-06-01 [PMID: 18465774] (Mouse)		Mouse
McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Mouse)		Mouse
Wu TG, Rose WA, Albrecht TB, Knutson EP, Konig R, Perdigao JR, Nguyen AP, Fleischmann WR IFN-alpha-induced murine B16 melanoma cancer vaccine cells: induction and accumulation of cell-associated IL-15. J. Interferon Cytokine Res., 2007-01-01;27(1):13-22. 2007-01-01 [PMID: 17266439] (Mouse)		Mouse
Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2006-11-02;109(5):2234-42. 2006-11-02 [PMID: 17082320] (Mouse)		Mouse
Show All 24 Publications. Collapse Publications.

Array DY447

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 Proteins and Enzymes
• IL-15 ELISAs