Mouse Fas Ligand/TNFSF6 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells. A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using MFL00	Applications	Species
Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity J Immunol, 2016-05-18;0(0):. 2016-05-18 [PMID: 27194786] (Mouse)		Mouse
de Claro RA, Zhu X, Tang J, Morgan-Stevenson V, Schwartz BR, Iwata A, Liles WC, Raines EW, Harlan JM Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state. Am. J. Pathol., 2011-05-06;178(6):2931-7. 2011-05-06 [PMID: 21550016] (Mouse)		Mouse
Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J. Immunol., 2010-11-22;186(1):556-62. 2010-11-22 [PMID: 21098223] (Mouse)		Mouse
Murthy A, Defamie V, Smookler DS Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J. Clin. Invest., 2010-07-12;120(8):2731-44. 2010-07-12 [PMID: 20628198] (Mouse)		Mouse
Beck JM, Preston AM, Wilcoxen SE, Morris SB, Sturrock A, Paine R Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected mice. Infect. Immun., 2009-01-05;77(3):1053-60. 2009-01-05 [PMID: 19124601] (Mouse)		Mouse
Bem RA, van Woensel JB, Bos AP, Koski A, Farnand AW, Domachowske JB, Rosenberg HF, Martin TR, Matute-Bello G Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection. Am. J. Physiol. Lung Cell Mol. Physiol., 2008-11-07;296(1):L46-56. 2008-11-07 [PMID: 18996903] (Mouse)		Mouse
Kierstein S, Krytska K, Sharma S, Amrani Y, Salmon M, Panettieri RA, Zangrilli J, Haczku A Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice. Allergy, 2008-04-01;63(4):438-46. 2008-04-01 [PMID: 18315731] (Mouse)		Mouse
Wetzel M, Li L, Harms KM, Roitbak T, Ventura PB, Rosenberg GA, Khokha R, Cunningham LA Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death Differ., 2007-10-26;15(1):143-51. 2007-10-26 [PMID: 17962815] (Mouse)		Mouse
Kovacic N, Lukic IK, Grcevic D, Katavic V, Croucher P, Marusic A The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. J. Immunol., 2007-03-15;178(6):3379-89. 2007-03-15 [PMID: 17339432] (Mouse)		Mouse
Niu J, Azfer A, Deucher MF, Goldschmidt-Clermont PJ, Kolattukudy PE Targeted cardiac expression of soluble Fas prevents the development of heart failure in mice with cardiac-specific expression of MCP-1. J. Mol. Cell. Cardiol., 2006-05-05;40(6):810-20. 2006-05-05 [PMID: 16678847] (Mouse)		Mouse
Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. Circulation, 2004-09-14;110(11):II194-9. 2004-09-14 [PMID: 15364862] (Mouse)		Mouse
Tanaka M, Nakae S, Terry RD, Mokhtari GK, Gunawan F, Balsam LB, Kaneda H, Kofidis T, Tsao PS, Robbins RC Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease. Blood, 2004-07-27;104(12):3789-96. 2004-07-27 [PMID: 15280201] (Mouse)		Mouse
Hao Z, Hampel B, Yagita H, Rajewsky K T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J. Exp. Med., 2004-05-17;199(10):1355-65. 2004-05-17 [PMID: 15148335] (Mouse)		Mouse
Show All 13 Publications. Collapse Publications.

Array MFL00

• Fas Ligand/TNFSF6 Antibodies
• Fas Ligand/TNFSF6 ELISA Kits
• Fas Ligand/TNFSF6 Lysate
• Fas Ligand/TNFSF6 Protein
• Fas Ligand/TNFSF6 Proteins and Enzymes
• Fas Ligand/TNFSF6 ELISAs