Mouse Fas Ligand/TNFSF6 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells. A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 2 of 2.

Publications using DY526	Applications	Species
Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology, 2012-10-01;1(7):1074-1083. 2012-10-01 [PMID: 23170255] (Mouse)		Mouse
Nikolov NP, Shimizu M, Cleland S Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood, 2010-05-10;116(5):740-7. 2010-05-10 [PMID: 20457871] (Mouse)		Mouse

Array DY526

• Fas Ligand/TNFSF6 Antibodies
• Fas Ligand/TNFSF6 ELISA Kits
• Fas Ligand/TNFSF6 Lysate
• Fas Ligand/TNFSF6 Protein
• Fas Ligand/TNFSF6 Proteins and Enzymes
• Fas Ligand/TNFSF6 ELISAs