Mouse Dkk-1 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 3 of 3.

Publications using DY1765	Applications	Species
Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register T, Freedman B, Monier-Faugere M, Malluche H, Hruska K CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder. J Am Soc Nephrol, 2014-02-27;25(8):1760-73. 2014-02-27 [PMID: 24578135] (Mouse)		Mouse
Leijten , Jeroen C, Moreira Teixeira , Liliana, Landman , Ellie B, van Blitterswijk , Clemens, Karperien , Marcel Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae. PLoS ONE, 2012-11-21;7(11):e49896. 2012-11-21 [PMID: 23185479] (Mouse)		Mouse
Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J. Bone Miner. Res., 2010-01-01;25(1):114-23. 2010-01-01 [PMID: 19580462] (Mouse)		Mouse

Array DY1765

• Dkk-1 Antibodies
• Dkk-1 Antibody Pair
• Dkk-1 ELISA Kit
• Dkk-1 Lysate
• Dkk-1 Proteins and Enzymes
• Dkk-1 ELISAs