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MMR/CD206/Mannose Receptor Antibody (5C11)

Images

 
Western Blot: MMR/CD206/Mannose Receptor Antibody (5C11) [H00004360-M02] - MRC1 monoclonal antibody (M02), clone 5C11. Analysis of MRC1 expression in human pancreas.
Immunohistochemistry-Paraffin: MMR/CD206/Mannose Receptor Antibody (5C11) [H00004360-M02] - Analysis of monoclonal antibody to MRC1 on formalin-fixed paraffin-embedded human placenta. Antibody concentration 1.5 ug/ml.
ELISA: MMR/CD206/Mannose Receptor Antibody (5C11) [H00004360-M02] - Detection limit for recombinant GST tagged MRC1 is approximately 0.03ng/ml as a capture antibody.

Product Details

Summary
Reactivity Hu, Fu, PmSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clone
5C11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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MMR/CD206/Mannose Receptor Antibody (5C11) Summary

Description
Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen
MRC1 (NP_002429, 22 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. TRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLY
Specificity
MRC1 (5C11)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MRC1
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:500
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control. It has been used for IHC-P. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 24874253).
Publications
Read Publications using H00004360-M02.

Reactivity Notes

Fungi reactivity reported in scientific literature (PMID: 25506589).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MMR/CD206/Mannose Receptor Antibody (5C11)

  • CD206
  • CLEC13D
  • CLEC13Dmacrophage mannose receptor 1
  • C-type lectin domain family 13 member D
  • mannose receptor, C type 1
  • MMR
  • MMRCD206 antigen
  • MRC1

Background

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MMR/CD206/Mannose Receptor Antibody (H00004360-M02)(23)

We have publications tested in 1 application: ICC/IF.


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Showing Publications 1 - 10 of 23. Show All 23 Publications.
Publications using H00004360-M02 Applications Species
Takuma M, Masato F, Ryosuke N et al. Comparison of Phenotypes in Subcutaneous Fat and Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting. Circ J. 2023-02-03 [PMID: 36740256]
Yuming L, Jinmai Z, Zhuo W et al. Multi-omics characterization reveals the pathogenesis of liver focal nodular hyperplasia. iScience. 2022-08-11 [PMID: 36060063]
Cheng P, Yukio F, Hasita H et al. Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects. Cancer Immunol Immunother. 2021-10-16 [PMID: 34655303]
Takanobu K, Rintaro O, Naing A et al. Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma. Sci Rep. 2021-01-13 [PMID: 33441903]
Eiichi O, Naing A, Rintaro O et al. The Distribution of Macrophage Subtypes and Their Relationship to Bone Morphogenetic Protein 2 in Calcified Aortic Valve Stenosis. Am J Transl Res. 2020-05-15 [PMID: 32509172]
ASMR Haque, M Moriyama, K Kubota, N Ishiguro, M Sakamoto, A Chinju, K Mochizuki, T Sakamoto, N Kaneko, R Munemura, T Maehara, A Tanaka, JN Hayashida, S Kawano, T Kiyoshima, S Nakamura CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production Sci Rep, 2019-10-10;9(1):14611. 2019-10-10 [PMID: 31601953]
Hussein K, Stucki-Koch A, M?ller A et al. Complement receptor-associated CD163+/CD18+/CD11c+/CD206-/CD209- expression profile in chronic histiocytic intervillositis of the placenta. Placenta. 2019-02-15 [PMID: 30955707]
Numaguchi R, Furuhashi M, Matsumoto M et al. Differential Phenotypes in Perivascular Adipose Tissue Surrounding the Internal Thoracic Artery and Diseased Coronary Artery. J Am Heart Assoc. 2019-03-07 [PMID: 30638109]
Ko A, Kang G, Hattler JB et al. Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy. J Neuroimmune Pharmacol 2018-09-07 [PMID: 30194646]
Wehrhan F, Buttner-Herold M, Distel L et al. Galectin 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas. BMC Cancer 2018-08-16 [PMID: 30115022]
Show All 23 Publications.

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Bioinformatics

Gene Symbol MRC1
Entrez
OMIM
Uniprot