MMR/CD206/Mannose Receptor Antibody (122D2.08)

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Bovine.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 2 of 2.

Publications using DDX0380P-100	Applications	Species
Jenvey CJ, Shircliff AL, Bannantine JP et al. Phenotypes of macrophages present in the intestine are impacted by stage of disease in cattle naturally infected with Mycobacterium avium subsp. paratuberculosis PLoS ONE 2019-05-23 [PMID: 31121006] (ICC/IF, Bovine)	ICC/IF	Bovine
Marquet F et al. Characterization of dendritic cells subpopulations in skin and afferent lymph in the swine model. PLoS One 2011-01-27 [PMID: 21298011]

Array DDX0380P-100

• MMR/CD206/Mannose Receptor Antibodies
• MMR/CD206/Mannose Receptor ELISA Kits
• MMR/CD206/Mannose Receptor Proteins
• MMR/CD206/Mannose Receptor Proteins and Enzymes