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MMP-24/MT5-MMP Antibody (143908) [Unconjugated]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
143908
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC924U-100UG
Alexa Fluor 405
IC924V-100UG
Alexa Fluor 532
FAB924X
Alexa Fluor 594
IC924T-100UG
Alexa Fluor 647
IC924R-100UG
Alexa Fluor 700
IC924N-100UG
Alexa Fluor 750
IC924S-100UG
Allophycocyanin/Cy7
FAB924APCCY7
Biotin
FAB924B
DyLight 350
FAB924D
DyLight 405
FAB924E
DyLight 488
FAB924K
DyLight 550
FAB924L
DyLight 594
FAB924M
DyLight 650
FAB924W
DyLight 680
FAB924Y
DyLight 755
FAB924Z
FITC
FAB924F
HRP
FAB924H
Janelia Fluor 525
FAB924JF525
Janelia Fluor 549
FAB924I
Janelia Fluor 585
FAB924JF585
Janelia Fluor 635
FAB924JF635
Janelia Fluor 646
FAB924J
Janelia Fluor 669
FAB924JF669
PE/Atto594
FAB924PEATT594
PE/Cy5.5
FAB924PECY55
PE/Cy7
FAB924PECY7
PerCP
FAB924C
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB924-SP
Carrier Free
IC924V-100UG
Carrier Free
IC924N-100UG
Carrier Free
IC924U-100UG
Carrier Free
IC924T-100UG
Carrier Free
IC924S-100UG
Carrier Free
IC924R-100UG
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MMP-24/MT5-MMP Antibody (143908) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant mouse MMP‑24/MT5-MMP
Arg125-Gln296
Accession # Q9R0S2
Specificity
Detects mouse MMP‑24/MT5-MMP in direct ELISAs and detects human and mouse MMP‑24/MT5-MMP in Western blots. In Western blots, less than 5% cross-reactivity with recombinant mouse (rm) MMP-3, rmMMP-9, and the catalytic domains of recombinant human MMP‑14, 15, and 16 is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
MMP24
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MMP-24/MT5-MMP Antibody (143908) [Unconjugated]

  • EC 3.4.24
  • EC 3.4.24.-
  • EC 3.4.24.80
  • matrix metallopeptidase 24 (membrane-inserted)
  • matrix metalloproteinase 24 (membrane-inserted)
  • matrix metalloproteinase-24
  • membrane-type 5 matrix metalloproteinase
  • Membrane-type matrix metalloproteinase 5
  • Membrane-type-5 matrix metalloproteinase
  • MMP24
  • MMP-24
  • MT5MMP
  • MT5-MMP
  • MT5-MMPMMP25
  • MT-MMP 5
  • MTMMP5
  • MT-MMP5

Background

MMP-24, also known as MT5-MMP, is a 62-65 kDa member of the M10 metallopeptidase family, a subfamily of MMPs. It is a type I transmembrane glycoprotein that is converted into a 58 kDa active form (amino acids [aa] 129-618) following removal of its propeptide. Proteolytic cleavage after Arg554 generates a 52 kDa active, soluble form that undergoes further cleavage in to 27-34 kDa fragment. MMP-24 has restricted expression, being found on neurons, mast cells, neural stem cells and ependymal cells lining the ventricles of the brain. It is known to cleave chondroitin sulfate, dermatan sulfate, pro-MMP-2, and N-Cadherin. Its activation of MMP-2 likely contributes to neurite outgrowth, while its cleavage of N-Cadherin in-trans between neural stem cells and ependymal initiates stem cell expansion and proliferation. Over amino acids 125-296, mouse MMP-24 shares 100% and 99% aa sequence identity with rat and human MMP-24, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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MAB924
MMP-24/MT5-MMP Antibody (143908) [Unconjugated]
Species: Hu, Mu
Applications: WB, Flow, CyTOF-ready

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Bioinformatics

Gene Symbol MMP24
Uniprot