Human MMP-2 ELISA Kit (Colorimetric)

This product is produced by and distributed for Abnova, a company based in Taiwan.

MMP2 is a member of the Matrix Metalloproteinase (MMP) family, which are involved in extracellular matrix degradation under both normal physiological and disease processes. Specifically, MMP-2 is responsible for degrading collagens type IV, V, VII, and X and gelatin type I. Other reported functions of MMP 2 include angiogenesis, tumor invasion, tissue repair, remodeling of the vasculature, inflammation, and atherosclerotic plaque rupture. MMP-2 secretion is activated by the Ras signaling pathway. MMP2 triggers cells to begin migration by cleaving laminin-5 and exposing an integrin-binding site on the epithelial basement membrane. The cleaved of laminin has been detected in tumors and in tissues being altered, howver the activated form of MMP2 is not found in benign tumors. Thus, detection of MMP2 is a possible early indicator of tumor activity. MMP2 is most strongly expressed in normal skin fibroblasts, but may also be found in gliomas, breast and prostate tumors. Mutations in the MMP-2 gene have been linked to Torg-Winchester syndrome, Nodulosis-Arthropathy-Osteolysis (NAO) syndrome, and arthritis. Additionally, abnormal expression of matrix matalloproteinases have been associated with neoplastic traits such as loss of negative growth regulation and high invasive potential.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using KA0391	Applications	Species
Basilico N, Magnetto C, D'Alessandro S et al. Dextran-shelled oxygen-loaded nanodroplets reestablish a normoxia-like pro-angiogenic phenotype and behavior in hypoxic human dermal microvascular endothelium. Toxicol Appl Pharmacol. 2015-08-11 [PMID: 26276311]
Lee JG, Dahi S, Mahimkar R et al. Intronic regulation of matrix metalloproteinase-2 revealed by in vivo transcriptional analysis in ischemia. Proc Natl Acad Sci U S A. 2005-11-08 [PMID: 16258061]
Morgunova E, Tuuttila A, Bergmann U et al. Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. Science. 1999-06-04 [PMID: 10356396]
Huhtala P, Eddy RL, Fan YS et al. Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16. Genomics. 1990-03-01 [PMID: 2158484]

Array KA0391

• MMP-2 Antibodies
• MMP-2 ELISA Kits
• MMP-2 Lysate
• MMP-2 Proteins
• MMP-2 ELISAs
• MMP-2 Proteins and Enzymes