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MMP-2 Antibody (8B4) [DyLight 488]

 (2 Publications)
 (1 Review)
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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IP, KD
Clone
8B4
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB200-114AF350
Alexa Fluor 405
NB200-114AF405
Alexa Fluor 488
NB200-114AF488
Alexa Fluor 532
NB200-114AF532
Alexa Fluor 594
NB200-114AF594
Alexa Fluor 647
NB200-114AF647
Alexa Fluor 700
NB200-114AF700
Alexa Fluor 750
NB200-114AF750
Biotin
NB200-114B
CoraFluor 1
NB200-114CL1
DyLight 350
NB200-114UV
DyLight 405
NB200-114V
DyLight 550
NB200-114R
DyLight 594
NB200-114DL594
DyLight 650
NB200-114C
DyLight 680
NB200-114FR
DyLight 755
NB200-114IR
FITC
NB200-114F
HRP
NB200-114H
Janelia Fluor 525
NB200-114JF525
Janelia Fluor 549
NB200-114JF549
Janelia Fluor 646
NB200-114JF646
Janelia Fluor 669
NB200-114JF669
Unconjugated
NB200-114
mFluor Violet 450 SE
NB200-114MFV450
mFluor Violet 500 SE
NB200-114MFV500
mFluor Violet 610 SE
NB200-114MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB200-114
BSA Free
NB200-114
BSA Free
NB200-114SS
Azide and BSA Free
NBP2-80854
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MMP-2 Antibody (8B4) [DyLight 488] Summary

Immunogen
Activated recombinant human MMP-2. [Uniprot: P08253]
Specificity
This is specific for pro and active MMP2.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MMP2
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Reviewed Applications
Read 1 Review rated 4
using
NB200-114G in the following applications:
Publications
Read Publications using
NB200-114G in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for MMP-2 Antibody (8B4) [DyLight 488]

  • 72 kDa gelatinase
  • CLG4
  • CLG4A72 kDa type IV collagenase
  • collagenase type IV-A
  • EC 3.4.24
  • EC 3.4.24.24
  • Gelatinase A
  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
  • matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase)
  • Matrix metalloproteinase-2
  • matrix metalloproteinase-II
  • MMP2
  • MMP-2
  • MMP-II
  • MONA
  • neutrophil gelatinase
  • TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)

Background

Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix matalloproteinases. MMP2, the signalling mechanism for cells to begin migration, triggers the movement when it splits laminin-5 and exposes and integrin-binding site on this component of epithelial basement membrane. The changed form of laminin was found in tumors and in tissues being altered. The activated form of MMP2, however, is not found in benign tumors. Thus detection of the enzyme is a possible early indicator of tumor activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MMP-2 Antibody (NB200-114G)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


Filter By Application
WB
(1)
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Filter By Species
Mouse
(2)
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Review for MMP-2 Antibody (NB200-114G) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using NB200-114G:
Filter by Applications
IHC-Fr
(1)
All Applications
Filter by Species
Mouse
(1)
All Species
Images Ratings Applications Species Date Details
  4
reviewed by:
Verified Customer
 IHC-Fr Mouse 11/30/2011
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample TestedMouse
SpeciesMouse

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for MMP-2 Antibody (NB200-114G) (0)

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Secondary Antibodies

 

Isotype Controls

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Research Areas for MMP-2 Antibody (NB200-114G)

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Blogs on MMP-2.

Check out the latest blog posts on MMP-2.
MMP-2: More Than a Cancer Marker
Matrix metalloproteinases (MMP) are a family of endopeptidases involved in the breakdown of extracellular matrix (ECM) during both normal physiological and disease processes. MMP-2 is a zinc-dependent family member that selectively cleaves collagen...  Read full blog post.
CD63: is it pro-metastatic or anti-metastatic?
CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,...  Read full blog post.
Integrin alpha v beta 3 - a target for inhibiting tumor angiogenesis
Integrins are a family of transmembrane proteins involved in diverse processes including cell adhesion, signal transduction, cell migration, and differentiation. They exist as heterodimers consisting of noncovalently linked alpha and beta subunits....  Read full blog post.
Cytokeratin 18 - A Intermediate Filament Cyotskeletal Component
Keratins, also called cytokeratins, are a family of filamentous structural proteins that form the intermediate filaments within epithelial cells. Keratins are differentially expressed depending on both the epithelial cell origin and degree of differen...  Read full blog post.
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Recent Reviews

4
5
0
4
1
3
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2
0
1
0
 
 Verified Customer
11/30/2011
Application: IHC-Fr
Species: Mouse
read this review

Bioinformatics

Gene Symbol MMP2