MFG-E8 Antibody (278901) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Milk Fat Globulin Protein E8 (MFG-E8), also known as Lactadherin, MP47, breast epithelial antigen BA46, and SED1, is a 66‑75 kDa pleiotropic secreted glycoprotein that promotes mammary gland morphogenesis, angiogenesis, and tumor progression. MFG-E8 also plays an important role in tissue homeostasis and the prevention of inflammation (1). Human MGF-E8 contains one N-terminal EGF-like domain and two C‑terminal F5/8-type discoidin-like domains (2). It shares 63% and 61% aa sequence identity with comparable regions of mouse and rat MFG-E8, respectively. Shorter isoforms of human MFG-E8 may have N-terminal deletions (beginning near the end of the first discoidin-like domain), internal deletions (lacking either the EGF-like domain or the central region of the second discoidin-like domain), or C‑terminal deletions (truncated within the second discoidin-like domain) (3). A 50 aa internal proteolytic fragment of human MFG-E8 (known as Medin) is a major component of aortic medial amyloid deposits (4). MFG-E8 is released into the milk in complex with lipid-containing milk fat globules. It is also found in multiple other cell types including endothelial cells and smooth muscle cells of the vasculature, immature dendritic cells, at the acrosomal cap of testicular and epididymal sperm, and in epithelial cells of the endometrium (1). MFG-E8 binds to the Integrins alpha V beta 3 and alpha V beta 5 and potentiates the angiogenic action of VEGF through VEGF R2 (5, 6). It reduces inflammation and tissue damage in a variety of settings. MFG-E8 functions as a bridge between phosphatidylserine on apoptotic cells and Integrin alpha V beta 3 on phagocytes, leading to the clearance of apoptotic debris (7). It mediates the engulfment of apoptotic bodies in atherosclerotic plaques and prion-infected brain (8, 9) and of apoptotic B cells during germinal center reactions (10, 11). MFG-E8 also promotes the removal of excess Collagen in fibrotic lungs and the regeneration of damaged intestinal epithelia (12, 13). Its tissue-protective role impairs anti‑tumor immunity and chemotherapy-induced apoptosis (14). MFG-E8 in the breastmilk blocks rotavirus infection in nursing babies (15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Development.

Showing Publications 1 - 5 of 5.

Publications using MAB2767	Applications	Species
Seda Kilinc, Rebekka Paisner, Roman Camarda, Suprit Gupta, Olga Momcilovic, Rebecca A. Kohnz et al. Oncogene-regulated release of extracellular vesicles Developmental Cell 2021-07-01 [PMID: 34118203]
Morayma M Temoche-Diaz, Matthew J Shurtleff, Randy Schekman Buoyant Density Fractionation of Small Extracellular Vesicle Sub-populations Derived from Mammalian Cells BIO-PROTOCOL 2020-08-05 [PMID: 33659370]
Morayma M Temoche-Diaz, Matthew J Shurtleff, Ryan M Nottingham, Jun Yao, Raj P Fadadu, Alan M Lambowitz et al. Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes eLife 2019-08-22 [PMID: 31436530]
Mingyi Wang, Zongming Fu, James Wu, Jing Zhang, Liqun Jiang, Benjamin Khazan et al. MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling Aging Cell 2012-06-01 [PMID: 22385834]
Lin YP, Hsu ME, Chiou YY Comparative proteomic analysis of rat aorta in a subtotal nephrectomy model. Proteomics, 2010-07-01;10(13):2429-43. 2010-07-01 [PMID: 20405472] (ELISA Development, Human)	ELISA Development	Human

Array MAB2767

• MFG-E8 Antibodies
• MFG-E8 Lysate
• MFG-E8 Protein
• MFG-E8 ELISAs
• MFG-E8 Proteins and Enzymes