MED23 Antibody

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: CoIP, IP, WB.

Showing Publications 1 - 4 of 4.

Publications using NB200-338	Applications	Species
Liu Z, Yao X, Yan G et al. Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nat Commun. 2016-04-01 [PMID: 27033977] (IP, Human)	IP	Human
Yao X, Tang Z, Fu X et al. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015-09-01 [PMID: 26330467] (CoIP, WB, Human)	CoIP, WB	Human
Chu Y, Gomez Rosso L, Huang P et al. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014-09-16 [PMID: 25223702] (IP, Mouse)	IP	Mouse
Terada N, Saitoh Y, Ohno N et al. Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves. Mol Cell Biol 2012-01-01 [PMID: 22025680]

Array NB200-338

• MED23 Antibodies
• MED23 Protein