Species: Hu, Mu, Rt
Applications: IP, ChIP, WB (-)
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: IP, WB (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IP (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
DRIPs are a distinct set of ligand-dependent proteins that interact with the vitamin D receptor (VDR). Together, these proteins constitute a new cofactor complex. DRIPs bind to several nuclear receptors to mediate ligand-dependent enhancement of transcription by VDR and the thyroid hormone receptor in cell-free transcription assays. The DRIPs are almost indistinguishable from components of another cofactor complex called ARC, which is recruited by other types of transcription activators to mediate transactivation on chromatin-assembled templates. The role of nuclear-receptor ligands may, in part, be to recruit such a cofactor complex to the receptor and, in doing so, to enhance transcription of target genes. In humans, interaction with Sur-2 is required for transcription to be activated by the activation domain of a transcription factor of the ETS-family in response to activated mitogen-activated protein (MAP) kinase.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
9439 |
| Alternate Names |
- 130 kDa transcriptional co-activator
- 133 kDa transcriptional co-activator
- CRSP130
- DRIP130DKFZp434H0117
- mediator complex subunit 23CRSP133
- Protein sur-2 homolog
- subunit 3, 130kDa
- Transcriptional coactivator CRSP130
- Vitamin D3 receptor-interacting protein complex 130 kDa component
|
