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MAG/Siglec-4a Antibody

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Immunohistochemistry-Paraffin: MAG/Siglec-4a Antibody [NBP1-81817] - Staining in human cerebral cortex and skeletal muscle tissues using anti-MAG antibody. Corresponding MAG RNA-seq data are presented for the same tissues.
Orthogonal Strategies: Immunohistochemistry-Paraffin: MAG/Siglec-4a Antibody [NBP1-81817] - Staining in human cerebral cortex and skeletal muscle tissues using anti-MAG antibody. Corresponding MAG RNA-seq data ...read more
Immunohistochemistry-Paraffin: MAG/Siglec-4a Antibody [NBP1-81817] - Staining of human skeletal muscle shows low expression as expected.
Immunohistochemistry-Paraffin: MAG/Siglec-4a Antibody [NBP1-81817] - MAG Antibody [NBP1-81817] - Image submitted by a verified customer review on mouse inner ear at 1:200 dilution.
Immunohistochemistry-Paraffin: MAG/Siglec-4a Antibody [NBP1-81817] - Staining of human cerebral cortex shows high expression.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

  

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MAG/Siglec-4a Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: DPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNE
Predicted Species
Rat (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MAG
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. MAG/Siglec-4a antibody validated for IHC-P from a verified customer review.
Control Peptide
MAG/Siglec-4a Protein (NBP1-81817PEP)
Reviewed Applications
Read 1 Review rated 5
using
NBP1-81817 in the following applications:
Publications
Read Publication using NBP1-81817.

Reactivity Notes

Mouse reactivity reported from a verified customer review.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for MAG/Siglec-4a Antibody

  • GMAsialic acid binding Ig-like lectin 4A
  • MAG
  • myelin associated glycoprotein
  • myelin-associated glycoprotein
  • sialic acid-binding immunoglobulin-like lectin 4A
  • Siglec4a
  • Siglec-4a
  • S-MAG

Background

Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MAG/Siglec-4a Antibody (NBP1-81817)(1)

We have publications tested in 1 confirmed species: Human.


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Review for MAG/Siglec-4a Antibody (NBP1-81817) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using NBP1-81817:
Filter by Applications
IHC-P
(1)
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Mouse
(1)
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Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin MAG/Siglec-4a NBP1-81817
Enlarge 		5
reviewed by:
Verified Customer
 IHC-P Mouse 10/28/2013
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Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedMouse inner ear
SpeciesMouse
LotA6820

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Secondary Antibodies

 

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Recent Reviews

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Immunohistochemistry-Paraffin MAG/Siglec-4a NBP1-81817
Enlarge
 Verified Customer
10/28/2013
Application: IHC-P
Species: Mouse
read this review

Bioinformatics

Gene Symbol MAG