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Lysine Hydroxylase 2/PLOD2 Antibody (408105) [Unconjugated]

 (6 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
408105
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB4445-SP
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Lysine Hydroxylase 2/PLOD2 Antibody (408105) [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Lysine Hydroxylase 2/PLOD2
Ala26-Pro758
Accession # NP_891988
Specificity
Detects human Lysine Hydroxylase 2/PLOD2 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
PLOD2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB4445 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Lysine Hydroxylase 2/PLOD2 Antibody (408105) [Unconjugated]

  • 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2
  • 2-oxoglutarate 5-dioxygenase 2
  • LH2
  • Lysine Hydroxylase 2
  • PLOD2
  • procollagen-lysine
  • telopeptide lysyl hydroxylase
  • TLH

Background

Lysine Hydroxylase 2 (LH2) also known as PLOD2 (procollagen-lysine, 2 oxoglutarate 5 dioxygenase 2) is a membrane-bound homodimeric enzyme localized to the cisternae of the rough ER. The enzyme catalyzes the hydroxylation of lysine residues in collagen-like peptides, which in turn serves as sites for carbohydrate attachment in collagen. Two alternatively spliced forms have 737 or 758 amino acids (aa). Human LH2 (758 aa form) shares 92.5% aa sequence identity with the appropriate isoform of mouse and rat LH2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Lysine Hydroxylase 2/PLOD2 Antibody (MAB4445)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IHC, IHC-P, Western Blot.


Filter By Application
IHC
(1)
IHC-P
(1)
Western Blot
(1)
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Human
(3)
All Species
Showing Publications 1 - 6 of 6.
Publications using MAB4445 Applications Species
Qiuyu Liu, Nasi Liu, Vera van der Noord, Wanda van der Stel, Bob van de Water, Erik H. J. Danen et al. Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia Breast Cancer Research and Treatment 2023-04-01 [PMID: 36826702]
CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 2022-02-21;11(0):. 2/21/2022 [PMID: 35188460]
RAF Gjaltema, D Goubert, C Huisman, CD Pilar Garc, M Koncz, PG Jellema, D Wu, U Brouwer, A Kiss, PJ Verschure, RA Bank, MG Rots KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFbeta1 Activation Int J Mol Sci, 2020-05-21;21(10):. 2020-05-21 [PMID: 32455614] (Western Blot, Human) Western Blot Human
Greenhough A, Bagley C, Heesom KJ et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis EMBO Mol Med 8/24/2018 [PMID: 30143543]
Jonathan Kurie Lysyl Hydroxylase 2 Is Secreted By Tumor Cells and Can Modify Collagen in the Extracellular Space J. Biol. Chem., 2016-11-01;0(0):. 2016-11-01 [PMID: 27803159] (IHC, Human) IHC Human
Chen , Yulong, Terajima , Masahiko, Yang , Yanan, Sun , Li, Ahn , Young-Ho, Pankova , Daniela, Puperi , Daniel S, Watanabe , Takeshi, Kim , Min P, Blackmon , Shanda H, Rodriguez , Jaime, Liu , Hui, Behrens , Carmen, Wistuba , Ignacio, Minelli , Rosalba, Scott , Kenneth, Sanchez-Adams , Johannah, Guilak , Farshid, Pati , Debanand, Thilaganathan , Nishan, Burns , Alan R, Creighton , Chad J, Martinez , Elisabet, Zal , Tomasz, Grande-Allen , K Jane, Yamauchi , Mitsuo, Kurie , Jonathan Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest, 2015-02-09;125(3):1147-62. 2015-02-09 [PMID: 25664850] (IHC-P, Human) IHC-P Human

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Bioinformatics

Gene Symbol PLOD2
Uniprot