LKB1/STK11 Antibody (873502) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LKB1, also known as STK11 and JBS, is a 55 kDa member of the CAMK Ser/Thr protein kinase family. It is ubiquitously expressed, and considered to be a tumor suppressor. LKB1 is both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle arrest and Wnt signaling. It is known to complex with STRAD and CAB39/MO25, and phosphorylate PTEN plus p53. Human LKB1 is 433 amino acids (aa) in length. It contains a protein kinase domain (aa 49‑309) and a prenylation motif (CysLysGlnGln) over aa 430‑433. Phosphorylation on Ser428 promotes the ability of LKB1 to suppress G361 cell growth. There are two potential isoforms of LKB1. One shows a nine aa insertion after Tyr126, while another shows a 34 aa substitution for aa 371‑433. Human LKB1 shares 90% aa sequence identity with mouse and rat LKB1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB8055

• LKB1/STK11 Antibodies
• LKB1/STK11 Lysate
• LKB1/STK11 Proteins