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Kv7.1 Antibody

Images

 
Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876] - Staining of human skin shows low expression as expected.
Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876] - Staining of human adrenal gland shows high expression.
Orthogonal Strategies: Immunohistochemistry-Paraffin: Kv7.1 Antibody [NBP2-31876] - Staining in human adrenal gland and skin tissues using anti-KCNQ1 antibody. Corresponding KCNQ1 RNA-seq data are presented for ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

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Kv7.1 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: PRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRR
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNQ1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Kv7.1 Recombinant Protein Antigen (NBP2-31876PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (88%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Kv7.1 Antibody

  • ATFB3
  • IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
  • JLNS1
  • KCNA8
  • KCNA8FLJ26167
  • KCNA9
  • KCNA9Kv1.9
  • KCNQ1
  • kidney and cardiac voltage dependend K+ channel
  • KQT-like 1
  • Kv7.1
  • KVLQT1
  • KVLQT1ATFB1
  • LQT
  • LQT1
  • potassium voltage-gated channel subfamily KQT member 1
  • potassium voltage-gated channel, KQT-like subfamily, member 1
  • RWS
  • slow delayed rectifier channel subunit
  • SQT2
  • Voltage-gated potassium channel subunit Kv7.1
  • WRS

Background

KCNQ1 encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described (from EntrezGene).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNQ1
Uniprot