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Nav1.5 Antibody (4G8:1G7)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, Func, ICC/IF, IHC, IP, CyTOF-ready
Clone
4G8:1G7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

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Nav1.5 Antibody (4G8:1G7) Summary

Immunogen
Peptide (14mer) from an extracellular domain of Nav1.5 - VSENIKLGNLSALR
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Gene
SCN5A
Purity
Thiophilic Chromatography
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/ Immunofluorescence 10 ug/ml
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Radioimmunoassay 1:100 - 1:2000
  • Western Blot 2 ug/ml
Application Notes
This antibody is CyTOF ready. Positive control(s): Cell lines over expressing Nav1.5, e.g Nav 1.5-HEK293 cells

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Thiophilic Chromatography

Alternate Names for Nav1.5 Antibody (4G8:1G7)

  • cardiac sodium channel alpha subunit
  • cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
  • CDCD2VF1
  • HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
  • HB2
  • HBBD
  • HH1CMD1E
  • ICCD
  • IVF
  • LQT3SSS1CMPD2
  • Nav1.5
  • PFHB1
  • SCN5A
  • Sodium channel protein cardiac muscle subunit alpha
  • sodium channel protein type 5 subunit alpha
  • sodium channel protein type V alpha subunit
  • Sodium channel protein type V subunit alpha
  • sodium channel, voltage-gated, type V, alpha subunit
  • Voltage-gated sodium channel subunit alpha Nav1.5

Background

Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signaling in nerves and muscles. Expression is also detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatory beta-subunit. Expression has been detected in a number of tumor cell lines and has been implicated in the metastatic behavior of breast and prostate cancer cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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FAQs for Nav1.5 Antibody (NB110-61010). (Showing 1 - 1 of 1 FAQ).

  1. The customer has requested to see any western blot data that you have available for this antibody.
    • For our product NB110-61010, we have validated the western blot application by customer review. Unfortunately, the customer review did not come with an image. As this is a listed application on our webpage, we will fully guarantee western blot detection of human Nav1.5 with this product. Here is a link of our guarantee for your customer's reference. I am sorry that we did not have the data requested by your customer. Please let me know if they have any additional questions.

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Bioinformatics

Gene Symbol SCN5A
Entrez