Isocitrate Dehydrogenase 1/IDH1 Products

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq]

Bioinformatics

Entrez	15926 Mouse 24479 Rat 3417 Human
Uniprot	AAH12846 Human NP_005887 Human NP_005887.2 Human O75874 Human
Product By Gene ID	3417
Alternate Names	Cytosolic NADP-isocitrate dehydrogenase EC 1.1.1.42 IDCD IDH IDP IDPC isocitrate dehydrogenase [NADP] cytoplasmic isocitrate dehydrogenase 1 (NADP+), soluble NADP(+)-specific ICDH NADP-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, peroxisomal Oxalosuccinate decarboxylase PICD

Research Areas for Isocitrate Dehydrogenase 1/IDH1

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Stem Cell Markers