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Integrin beta 3/CD61 Antibody (909114) [Unconjugated]

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P815 mouse mastocytoma cell line was stained with Rat Anti-Mouse Integrin beta 3/CD61 Monoclonal Antibody (Catalog # MAB41182, filled histogram) or isotype control antibody (Catalog # MAB005, open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0113).
P815 mouse mastocytoma cell line was stained with Rat Anti-Mouse Integrin beta 3/CD61 Monoclonal Antibody (Catalog # MAB41182, filled histogram) or isotype control antibody (Catalog # MAB005, open histogram), followed ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
909114
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB41182U-100UG
Alexa Fluor 405
FAB41182V-100UG
Alexa Fluor 488
FAB41182G-100UG
Alexa Fluor 532
FAB41182X
Alexa Fluor 594
FAB41182T-100UG
Alexa Fluor 647
FAB41182R-100UG
Alexa Fluor 700
FAB41182N-100UG
Alexa Fluor 750
FAB41182S-100UG
Allophycocyanin
FAB41182A
Allophycocyanin/Cy7
FAB41182APCCY7
Biotin
FAB41182B
CoraFluor 1
FAB41182CL1
DyLight 350
FAB41182D
DyLight 405
FAB41182E
DyLight 488
FAB41182K
DyLight 550
FAB41182L
DyLight 594
FAB41182M
DyLight 650
FAB41182W
DyLight 680
FAB41182Y
DyLight 755
FAB41182Z
FITC
FAB41182F
HRP
FAB41182H
Janelia Fluor 525
FAB41182JF525
Janelia Fluor 549
FAB41182I
Janelia Fluor 585
FAB41182JF585
Janelia Fluor 635
FAB41182JF635
Janelia Fluor 646
FAB41182J
Janelia Fluor 669
FAB41182JF669
PE/Atto594
FAB41182PEATT594
PE/Cy5.5
FAB41182PECY55
PE/Cy7
FAB41182PECY7
PerCP
FAB41182C
mFluor Violet 450 SE
FAB41182MFV450
mFluor Violet 500 SE
FAB41182MFV500
mFluor Violet 610 SE
FAB41182MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
FAB41182V-100UG
Carrier Free
FAB41182U-100UG
Carrier Free
FAB41182T-100UG
Carrier Free
FAB41182S-100UG
Carrier Free
FAB41182R-100UG
Carrier Free
FAB41182N-100UG
Carrier Free
FAB41182G-100UG
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Integrin beta 3/CD61 Antibody (909114) [Unconjugated] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin alpha 2b and Integrin beta 3 linked heterodimer
Leu32-Arg988 (Integrin alpha 2b) & Glu26-Asp717 (Integrin beta 3)
Accession # NP_034705 (Integrin alpha 2b) & O54890 (Integrin beta 3)
Specificity
Detects mouse Integrin  beta 3/CD61 in direct ELISA.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
ITGB3
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/mL
Publications
Read Publication using
MAB41182 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin beta 3/CD61 Antibody (909114) [Unconjugated]

  • CD61 antigen
  • CD61
  • GP3A
  • GP3Aplatelet glycoprotein IIIa
  • GPIIIA
  • GPIIIaintegrin beta-3
  • INGRB3
  • Integrin beta 3
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • ITG B3
  • ITGB3
  • Platelet membrane glycoprotein IIIa

Background

Integrin beta 3 (ITGB3) is also known as platelet glycoprotein IIIa (GPIIIa) and CD61. Integrins are integral cell-surface proteins known to participate in both cell adhesion and cell-surface mediated signaling. They are composed of an alpha chain and a beta chain. ITGB3 is an integrin beta chain that forms a heterodimer with alpha-IIb or alpha-V chains. It is involved in platelet aggregation, and serves as an anchor for fibrinogen, allowing platelets to form aggregates or clots. A functional absense of ITGB3 leads to Glanzmann's thrombasthenia, a condition where platelets are activated, but fail to form an aggregate. Alternatively spliced transcripts encoding different proteins have been described, in human.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin beta 3/CD61 Antibody (MAB41182)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.


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