INSL3 Antibody

Insulin-like 3 (INSL3), a member of the insulin-like hormone superfamily, is specifically expressed in Leydig cells of the fetal and postnatal testis and in theca cells of the postnatal ovary. It is synthesized as a 131-amino acid preproprotein, which contains a 24-amino acid signal peptide. The human INSL3 gene is assigned to bands p13.2-p12 of the short arm of chromosome 19 with the similar organization to that of insulin and relaxin. INSL3 induces gubernaculum development in an androgen-independent way, while androgen-mediated regression of the CSL occurs independently from Insl3. Moreover, INSL3 is a ligand for LGR8 and INSL3-LGR8 mutations are believed to be associated with human cryptorchidism.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Cynomolgus Monkey.

We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-P.

Showing Publications 1 - 8 of 8.

Publications using NBP1-81223	Applications	Species
Daoyuan Huang, Yuesheng Zuo, Chen Zhang, Guoqiang Sun, Ying Jing, Jinghui Lei, Shuai Ma, Shuhui Sun, Huifen Lu, Yusheng Cai, Weiqi Zhang, Fei Gao, Andy Peng Xiang, Juan Carlos Izpisua Belmonte, Guang-Hui Liu, Jing Qu, Si Wang A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis Protein & Cell 2023-12-01 [PMID: 36929025]
Massimo Alfano, Anna Sofia Tascini, Filippo Pederzoli, Irene Locatelli, Manuela Nebuloni, Francesca Giannese, Jose Manuel Garcia-Manteiga, Giovanni Tonon, Giada Amodio, Silvia Gregori, Alessandra Agresti, Francesco Montorsi, Andrea Salonia Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia Nature Communications 2021-09-01 [PMID: 34471128]
Wang M, Liu X, Chang G et al. Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis. Cell Stem Cell 2018-08-24 [PMID: 30174296] (ICC/IF, Human)	ICC/IF	Human
Lardone MC, Argandona F, Florez M et al. Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome. Andrology 2017-01-01 [PMID: 27769104]
Marie Berg Nygaard, Kristian Almstrup, Louise Lindbaek et al. Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells. Scientific Reports 2015-01-01 [PMID: 25992706] (ICC/IF, Human)	ICC/IF	Human
Djureinovic D, Fagerberg L, Hallstrom B et al. The human testis-specific proteome defined by transcriptomics and antibody-based profiling. Mol Hum Reprod 2014-06-01 [PMID: 24598113]
Huang D, Zuo Y, Zhang C et al. A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis Protein & Cell 2022-11-18 (IHC-P, Cynomolgus Monkey) Details: testicular tissues dilution used 1:500	IHC-P	Cynomolgus Monkey
Song K, Yang X, An G et al. Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models Nature communications 2022-11-28 [PMID: 36443325] (IF/IHC, Human)	IF/IHC	Human

Array NBP1-81223

• INSL3 Antibodies
• INSL3 ELISA Kit
• INSL3 Lysate
• INSL3 Protein