IL-6 Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length expressed as a 22-28 kDA molecular weight protein. IL-6 shares 39% aa sequence identity with mouse and rat IL-6. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor. IL-6, along with TNF-alpha and IL-1, function to drive the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate - Papio cynocephalus (Yellow Baboon).

We have publications tested in 9 applications: Antibody Array Development, Array Development, Bioassay, ELISA Capture, ELISA Detection, ELISA Development, ELISA Development (Detection), Electrochemiluminescent Assay, Functional Assay.

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using BAF206	Applications	Species
Hong, J;Son, M;Sin, J;Kim, H;Chung, DK; Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation Nutrients 2023-11-09 [PMID: 38004123] (ELISA Detection, Human)	ELISA Detection	Human
Newman, S;Wilson, B;Mamerow, D;Wollant, B;Nyein, H;Rosenberg-Hasson, Y;Maecker, H;Eisenstein, M;Soh, H; Extending the dynamic range of biomarker quantification through molecular equalization bioRxiv 2023-01-01 [PMID: 37443317] (Bioassay, Human)	Bioassay	Human
Chi-An Cheng, Li-Chiao Chiang, Yu-Syuan Chu Integrated pipeline for ultrasensitive protein detection in cancer nanomedicine† RSC Advances 5/9/2023 [PMID: 37197682]
R Lei, H Arain, M Obaid, N Sabhnani, C Mohan Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases Biosensors, 2022-09-14;12(9):. 2022-09-14 [PMID: 36140141] (ELISA Detection, Human)	ELISA Detection	Human
Mohammad Rahbar, Yuling Wu, J. Anand Subramony, Guozhen Liu Sensitive Colorimetric Detection of Interleukin-6 via Lateral Flow Assay Incorporated Silver Amplification Method Frontiers in Bioengineering and Biotechnology 11/26/2021 [PMID: 34900966]
Marina Chan, Siddharth Vijay, John McNevin, M Juliana McElrath, Eric C Holland, Taranjit S Gujral Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release Molecular Systems Biology 9/6/2021 [PMID: 34486798]
Xu Wang, David R. Walt Simultaneous detection of small molecules, proteins and microRNAs using single molecule arrays† Chemical Science 7/8/2020 [PMID: 34094160]
K Bernau, JP Leet, H Floerke, EM Bruhn, AL Noll, IS McDermott, S Esnault, NN Jarjour, N Sandbo Interleukin-1&alpha Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation Cells, 2021-03-02;10(3):. 2021-03-02 [PMID: 33801398] (ELISA Detection, Human)	ELISA Detection	Human
Fatemeh Khodadadei, Allen P. Liu, Carolyn A. Harris A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure Communications Biology 3/23/2021 [PMID: 33758339]
L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity Sci Rep, 2020-10-15;10(1):17444. 2020-10-15 [PMID: 33060625] (ELISA Capture, Human)	ELISA Capture	Human
Mehdi Bouhaddou, Danish Memon, Bjoern Meyer, Kris M. White, Veronica V. Rezelj, Miguel Correa Marrero et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection Cell 8/1/2020 [PMID: 32645325]
MF Abas?yan?k, K Wolfe, H Van Phan, J Lin, B Laxman, SR White, PA Verhoef, GM Mutlu, B Patel, S Tay Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes Nat Commun, 2020-05-25;11(1):2607. 2020-05-25 [PMID: 32451375] (Bioassay, Human)	Bioassay	Human
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 9/1/2020 [PMID: 32168040]
JS Hook, M Cao, K Weng, N Kinnare, JG Moreland Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4 J. Immunol., 2019-12-23;0(0):. 2019-12-23 [PMID: 31871022] (ELISA Detection, Human)	ELISA Detection	Human
X Sun, Q Qu, Y Lao, M Zhang, X Yin, H Zhu, Y Wang, J Yang, J Yi, M Hao Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer BMC Cancer, 2019-12-03;19(1):1180. 2019-12-03 [PMID: 31795965] (ELISA Detection, Human)	ELISA Detection	Human
A Stumpf, T Brandstett, J Hübner, J Rühe Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum PLoS ONE, 2019-12-02;14(12):e0225525. 2019-12-02 [PMID: 31790441] (ELISA Detection, Human)	ELISA Detection	Human
Defne Bayik, Debra Tross, Lydia A. Haile, Daniela Verthelyi, Dennis M. Klinman Regulation of the maturation of human monocytes into immunosuppressive macrophages Blood Advances 12/12/2017 [PMID: 29296902]
R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972. 2017-08-09 [PMID: 28793286] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma PLoS ONE, 2017-04-14;12(4):e0175712. 2017-04-14 [PMID: 28410380] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Olaf Pinkenburg The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus PLoS ONE, 2016-06-06;11(6):e0156929. 2016-06-06 [PMID: 27273104] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Agnetha Folestad, Martin Ålund, Susanne Asteberg, Jesper Fowelin, Ylva Aurell, Jan Göthlin et al. Offloading treatment is linked to activation of proinflammatory cytokines and start of bone repair and remodeling in Charcot arthropathy patients Journal of Foot and Ankle Research 12/10/2015 [PMID: 26692902]
Manfè Valentina, Fleckner Jan, Nørby Lisby Peder, Zhang Bo, Dai Hongjie, Keller Pernille Cytokine detection and simultaneous assessment of rheumatoid factor interference in human serum and synovial fluid using high-sensitivity protein arrays on plasmonic gold chips BMC Biotechnology 12/1/2015 [PMID: 26268325]
Voltolini C, Battersby S, Novembri R, Torricelli M, Severi F, Petraglia F, Norman J Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition. Endocrinology, 2014-11-26;156(2):670-9. 2014-11-26 [PMID: 25426872] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Elizabeth England, Philip Newton, Frances Neal, Lisa Kitching, Caroline Colley, Christine J. Rossant Application of the Mirrorball High-Sensitivity Cytometer to Multiplexed Assays for Antibody Drug Discovery J Biomol Screen 4/1/2015 [PMID: 25381256]
Schillace R, Skinner A, Pommier R, O'Neill S, Muller P, Naik A, Hansen J, Pommier S Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations. BMC Cancer, 2014-09-30;14(0):733. 2014-09-30 [PMID: 25269750] (Functional Assay, Human)	Functional Assay	Human
Oscar Alvarez-Garcia, Nicole H. Rogers, Roy G. Smith, Martin K. Lotz Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1 Arthritis & Rheumatology 7/1/2014 [PMID: 24591481]
Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci, 2011-09-01;26(9):1132-9. 2011-09-01 [PMID: 21935266] (ELISA Development, Human)	ELISA Development	Human
Zepp JA, Nold-Petry CA, Dinarello CA, Nold MF Protection from RNA and DNA viruses by IL-32. J. Immunol., 2011-02-23;186(7):4110-8. 2011-02-23 [PMID: 21346229] (Electrochemiluminescent Assay, Human)	Electrochemiluminescent Assay	Human
Lasse Saaby, Anna Katharina Jäger, Lise Moesby, Erik Wind Hansen, Søren Brøgger Christensen Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.) Phytotherapy Research 2/1/2011 [PMID: 20632303]
Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J. Immunol., 2009-10-07;183(9):5799-806. 2009-10-07 [PMID: 19812208] (ELISA Development, Human)	ELISA Development	Human
Hu H, Kwun J, Aizenstein BD, Knechtle SJ Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation, 2009-06-27;87(12):1814-20. 2009-06-27 [PMID: 19543058] (Antibody Array Development, Human)	Antibody Array Development	Human
Osei-Kumah A, Smith R, Clifton VL Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Cytokine, 2008-07-17;43(2):187-93. 2008-07-17 [PMID: 18639465] (ELISA Development, Human)	ELISA Development	Human
Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA Endogenous IL-32 controls cytokine and HIV-1 production. J. Immunol., 2008-07-01;181(1):557-65. 2008-07-01 [PMID: 18566422] (Electrochemiluminescent Assay, Human)	Electrochemiluminescent Assay	Human
Mitchell CM, Balkus J, Agnew KJ, Cohn S, Luque A, Lawler R, Coombs RW, Hitti JE Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines. AIDS Res. Hum. Retroviruses, 2008-05-01;24(5):667-71. 2008-05-01 [PMID: 18462081] (ELISA Development, Human)	ELISA Development	Human
Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. Stem Cells, 2007-10-25;26(1):279-89. 2007-10-25 [PMID: 17962701] (ELISA Development, Human)	ELISA Development	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA Development, Human)	ELISA Development	Human
Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol., 2006-02-02;172(1):156-65. 2006-02-02 [PMID: 16457895] (ELISA Development, Human)	ELISA Development	Human
Chen DS, Soen Y, Stuge TB Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray. PLoS Med., 2005-09-20;2(10):e265. 2005-09-20 [PMID: 16162034] (Functional Assay, Human)	Functional Assay	Human
Holst RM, Mattsby-Baltzer I, Wennerholm UB, Hagberg H, Jacobsson B Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand, 2005-06-01;84(6):551-7. 2005-06-01 [PMID: 15901266] (ELISA Development, Human)	ELISA Development	Human
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5. 2004-12-01 [PMID: 15585763] (ELISA Development, Human)	ELISA Development	Human
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (Array Development, Human)	Array Development	Human
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest., 2003-08-01;112(4):598-607. 2003-08-01 [PMID: 12925700] (ELISA Development, Human)	ELISA Development	Human
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (ELISA Development, Human)	ELISA Development	Human
Hess S, 2019, Rheinheimer C, Tidow F, Bartling G, Kaps C, Lauber J, Buer J, Klos A The reprogrammed host: Chlamydia trachomatis-induced up-regulation of glycoprotein 130 cytokines, transcription factors, and antiapoptotic genes. 7046, 2001-10-01;44(10):2392-401. 2001-10-01 [PMID: 11665982] (ELISA Development, Human)	ELISA Development	Human
Kinasewitz GT, 2016, Chang AC, Peer GT, Hinshaw LB, Taylor FB Peritonitis in the baboon: a primate model which stimulates human sepsis. 2000-02-01;13(2):100-9. 2000-02-01 [PMID: 10670839] (ELISA Development, Primate - Papio cynocephalus (Yellow Baboon))	ELISA Development	Primate - Papio cynocephalus (Yellow Baboon)
Show All 45 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	ELISA	Human	01/12/2015	View Summary Application ELISA Sample Tested See PMID 22813435 Species Human

Array BAF206

• IL-6 Antibodies
• IL-6 Antibody Pair
• IL-6 ELISA Kits
• IL-6 Lysate
• IL-6 Proteins
• IL-6 Proteins and Enzymes
• IL-6 ELISAs