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IL-22 Antibody (142906) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA(Cap)
Clone
142906
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB7822-SP
Carrier Free
MAB7822-500
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IL-22 Antibody (142906) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human IL-22
Ala34-Ile179
Accession # Q9GZX6
Specificity
Detects human IL-22 in direct ELISAs and Western blots. Shows 100% cross‑reactivity with recombinant mouse (rm) IL-22 and recombinant rat IL-22 and no cross-reactivity with recombinant human IL-10. In sandwich ELISAs, no cross-reactivity was observed with rmIL-22, rrIL-22, rhIL-10, rhIL-22BP, or rhIL-22 R.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL22
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.5-2.0 ug/mL
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Detection: Human IL-22 Biotinylated Antibody (Catalog number BAM7821)
Standard: Recombinant Human IL-22 (Catalog number 782-IL)
Publications
Read Publications using
MAB7822 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-22 Antibody (142906) [Unconjugated]

  • Cytokine Zcyto18
  • IL-10-related T-cell-derived inducible factor
  • IL22
  • IL-22
  • IL-D110
  • IL-TIF
  • ILTIFIL-10-related T-cell-derived-inducible factor
  • IL-TIFMGC79382
  • interleukin 22
  • interleukin-22
  • MGC79384
  • TIFa
  • TIFIL-23
  • zcyto18

Background

Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta , share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate
STAT‑1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22 R (previously an orphan receptor named CRF2-9) and
IL-10 R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.

  1. Dumoutier, L. et al., (2000) J. Immunol. 164:1814.
  2. Xie, M-H. et al., (2000) J. Biol. Chem. 275:31335.
  3. Dumoutier, L. et al., (2000) PNAS 97:10144.
  4. Kotenko, S.V. et al., (2001) J. Biol. Chem. 276:2725.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-22 Antibody (MAB7822)(8)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ELISA Development, ELISA Development (Capture), ELISpot Development.


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ELISA Development
(1)
ELISA Development (Capture)
(1)
ELISpot Development
(1)
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(2)
Mouse
(1)
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Showing Publications 1 - 8 of 8.
Publications using MAB7822 Applications Species
Hong Ki Min, Jeonghyeon Moon, Seon-Yeong Lee, A Ram Lee, Chae Rim Lee, Jennifer Lee et al. Expanded IL-22+ Group 3 Innate Lymphoid Cells and Role of Oxidized LDL-C in the Pathogenesis of Axial Spondyloarthritis with Dyslipidaemia Immune Network 11/18/2021 [PMID: 35036030]
Martina Kunkl, Carola Amormino, Simone Frascolla, Manolo Sambucci, Marco De Bardi, Silvana Caristi et al. CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes Frontiers in Immunology 10/14/2020 [PMID: 33178223]
Wen‑Bin Zheng, Lu‑Jiao Li, Di‑Chen Zhao, Ou Wang, Yan Jiang, Wei‑Bo Xia et al. A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1 Molecular Medicine Reports 6/12/2020 [PMID: 32627016]
J Zhang, IM Friberg, A Kift-Morga, G Parekh, MP Morgan, AR Liuzzi, CY Lin, KL Donovan, CS Colmont, PH Morgan, P Davis, I Weeks, DJ Fraser, N Topley, M Eberl Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections Kidney Int, 2017-03-17;0(0):. 2017-03-17 [PMID: 28318629] (ELISA Development (Capture), Human) ELISA Development (Capture) Human
Jeremy A Sullivan, Ewa Jankowska-Gan, Subramanya Hegde, Matthew A Pestrak, Vrushali V Agashe, Arick C Park et al. Th17 Responses to Collagen Type V, k alpha 1-Tubulin, and Vimentin Are Present Early in Human Development and Persist Throughout Life American Journal of Transplantation 4/1/2017 [PMID: 27801552]
Stephan Meller, Jeremy Di Di Domizio, Kui S Voo, Heike C Friedrich, Georgios Chamilos, Dipyaman Ganguly et al. T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 Nature Immunology 9/1/2015 [PMID: 26168081]
Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett., 2009-11-04;127(2):150-6. 2009-11-04 [PMID: 19895848] (ELISA Development, Human) ELISA Development Human
Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med., 2008-02-10;14(3):275-81. 2008-02-10 [PMID: 18264110] (ELISpot Development, Mouse) ELISpot Development Mouse

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Bioinformatics

Gene Symbol IL22
Uniprot