IL-22 Products

Description

Interleukin-22 (IL-22 or IL-TIF (IL-10-related T-cell derived inducible factor)) belongs to the IL-10 family of regulatory cytokines which also includes IL-10, IL-19, IL-20, IL-24 and IL-26. IL-22 is produced by T lymphocytes following anti-CD3 stimulation. It inhibits IL-4 production of Th2 cells, activates STAT-1 and STAT-3 in several hepatoma cell lines and upregulates the production of acute phase proteins. It may also be involved in inflammatory responses. Human and mouse IL-22 share 79% amino acid identity. Recombinant human IL-22 is a non-disulfide linked homodimer, signaling through a receptor complex of two subunits, IL-22R and IL-10R-beta, belonging to the class II cytokine receptor family.

Bioinformatics

Entrez	50616 Human 50929 Mouse
Uniprot	NM_020525 Human NP_065386 Human NP_065386.1 Human Q9GZX6 Human Q9JJY9 Mouse
Product By Gene ID	50616
Alternate Names	Cytokine Zcyto18 IL-10-related T-cell-derived inducible factor IL-D110 ILTIFIL-10-related T-cell-derived-inducible factor IL-TIFMGC79382 interleukin 22 interleukin-22 MGC79384 TIFa TIFIL-23 ZCYTO18 zcyto18

Research Areas for IL-22

Find related products by research area and learn more about each of the different research areas below.

Biologically Active Proteins
Cytokine Research

Related IL-22 Blog Posts

Check out the latest blog posts on IL-22.

PPAR gamma - An important target in human metabolism Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells by interacting with members of the nuclear hormone receptor superfamily known as peroxisome proliferator activated receptors (PPARs). There are f...    Read more.

Toll-like receptors in the intestinal epithelial cells By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ...    Read more.

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