IL-15R alpha Antibody (888220) [Janelia Fluor® 585]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

IL15RA is a gene that codes for a protein that is a high-affinity receptor for interleukin-15, and can signal in both cis and trans to neighboring IL2RG-expressing cells, but the expression of different isoforms may interfere with this signal transduction, as isoforms 5-8 do not bind to IL15. The isoforms are all highly expressed in the brain, with isoform 1 being the longest with a 267 amino acid chain and a weight of approximately 28 kDa. Current studies are being done on several diseases and disorders relating to this gene including lymphoma, systemic lupus erythematosus, anemia, inflammatory bowel disease, leukemia, bronchiolitis, rheumatoid arthritis, hepatitis B, gingivitis, lung cancer and Alzheimer's disease. IL15Ra has also been shown to have interactions with SYK, IL2RB, TRAF2, and AXL in pathways such as the IL-15 signlaing, TCR signaling, and IgA production pathways.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array FAB5511JF585

• IL-15R alpha Antibodies
• IL-15R alpha Lysates
• IL-15R alpha Proteins and Enzymes
• IL-15R alpha ELISA