Recombinant Human IL-15 Protein

Human Interleukin-15 (IL-15) is expressed by the IL15 gene located on the chromosome 4. It shares approximately 97 % and 73 % sequence identity with simian and murine IL-15, respectively. Both human IL-15 and simian IL-15 are active on murine cells. IL-15 is secreted by mononuclear phagocytes (and some other cells), especially macrophages following infection by virus. It possesses a variety of biological functions, including stimulating and maintaining of cellular immune responses, especially regulating T and natural killer (NK) cell activation and proliferation. In additionally, it shares many biological properties with IL- 2, including T, B and NK cell-stimulatory activities. IL-15 signals through a complex composed of IL-2/IL-15 receptor beta chain. Although IL-15 lacks sequence homology with IL-2, it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling. In addition, an IL-15 specific binding protein has also been cloned from a mouse T cell clone.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publication using NBP2-35020	Applications	Species
Huang B, Liu R, Wang P et al. CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer J Immunother Cancer 2020-06-01 [PMID: 32606053]

Array NBP2-35020

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 Proteins and Enzymes
• IL-15 ELISAs