IL-15 Antibody (34505) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 (1-3). Mature human IL-15 shares 70% amino acid sequence identity with mouse and rat IL-15. Alternate splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (4). IL-15 binds with high affinity to IL-15 R alpha (5). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (1, 6). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (7, 8). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (9). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (8, 10). Soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding or alternate splicing (11-13). These molecules retain the ability to bind tightly to IL-15 and can either inhibit or augment IL-15 function (5, 12, 13). Consistent with its shared use of IL-2 receptor subunits, IL-15 induces IL-2-like effects in lymphocyte development and homeostasis (3). It is particularly important for the maintenance and activation of NK cells and CD8⁺ memory T cells (3). IL-15 also exerts pleiotropic effects on other hematopoietic cells and non-immune cells (2). Ligation of membrane-associated IL-15/IL-15 R alpha complexes induces reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL-15/IL-15 R alpha expressing cells (14, 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 8 applications: ELISA Development, Flow Cytometry, ICC, IHC-Fr, IHC-P, Luminex Development, Neutralization, Western Blot.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using MAB647	Applications	Species
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 2020-09-01 [PMID: 32168040]
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling Sci Rep, 2016-09-02;6(0):32320. 2016-09-02 [PMID: 27586092] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
Karol Sestak, Hazel Thwin, Jason Dufour, David X. Liu, Xavier Alvarez, David Laine et al. Supplementation of Reduced Gluten Barley Diet with Oral Prolyl Endopeptidase Effectively Abrogates Enteropathy-Associated Changes in Gluten-Sensitive Macaques Nutrients 2016-06-28 [PMID: 27367722]
Periolo N, Guillen L, Arruvito M, Alegre N, Niveloni S, Hwang J, Bai J, Chernavsky A IL-15 controls T cell functions through its influence on CD30 and OX40 antigens in Celiac Disease. Cytokine, 2014-03-14;67(1):44-51. 2014-03-14 [PMID: 24680481] (Human)		Human
Saghafian-Hedengren S, Sohlberg E, Theorell J, Carvalho-Queiroz C, Nagy N, Persson J, Nilsson C, Bryceson Y, Sverremark-Ekstrom E Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells. J Virol, 2013-10-02;87(24):13446-55. 2013-10-02 [PMID: 24089567] (Neutralization, Human)	Neutralization	Human
Kai-ping Han, Xiaoyun Zhu, Bai Liu, Emily Jeng, Lin Kong, Jason L. Yovandich et al. IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization Cytokine 2011-12-01 [PMID: 22019703]
D K Finch, A Midha, C L Buchanan, D Cochrane, R I Craggs, S Cruwys et al. Identification of a potent anti-IL-15 antibody with opposing mechanisms of action in vitro and in vivo British Journal of Pharmacology 2011-01-01 [PMID: 20942844]
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (Luminex Development, Human)	Luminex Development	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (Luminex Development, Human)	Luminex Development	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (Luminex Development, Human)	Luminex Development	Human
Rhoton-Vlasak A, Hardt N Histological characteristics and altered expression of interleukins (IL) IL-13 and IL-15 in endometria of levonorgestrel users with different uterine bleeding patterns. Fertil. Steril., 2005-03-01;83(3):659-65. 2005-03-01 [PMID: 15749495] (IHC-P, Human)	IHC-P	Human
Piskin G, Tursen U, Sylva-Steenland RM, Bos JD, Teunissen MB Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23. Exp. Dermatol., 2004-12-01;13(12):764-72. 2004-12-01 [PMID: 15560760] (IHC-Fr, Human)	IHC-Fr	Human
Yamasaki S, Maeda M, Ohshima K, Kikuchi M, Otsuka T, Harada M Growth and apoptosis of human natural killer cell neoplasms: role of interleukin-2/15 signaling. Leuk. Res., 2004-10-01;28(10):1023-31. 2004-10-01 [PMID: 15289013] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood, 2004-07-08;104(10):3267-75. 2004-07-08 [PMID: 15242871] (ICC, Human)	ICC	Human
Searle RF, Bromage SJ, Palmer J, Curry JE, Lang AK Human amniotic fluid lacks interleukin-2 and interleukin-15 but can interact with the beta-chain of the interleukin-2 receptor. Immunology, 2000-03-01;99(3):411-7. 2000-03-01 [PMID: 10712671] (ELISA Development, Human)	ELISA Development	Human
Show All 15 Publications. Collapse Publications.

Array MAB647

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes