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IGF-I R/IGF1R Antibody (IGF1R/4667)

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Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human colon carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human breast carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
Protein Array: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Analysis of Protein Array containing more than 19,000 full-length human proteins using IGF-I R/IGF1R Antibody (IGF1R/4667).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, Func, ICC/IF, IHC, MA
Clone
IGF1R/4667
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-14094AF350
Alexa Fluor 405
NBP3-14094AF405
Alexa Fluor 488
NBP3-14094AF488
Alexa Fluor 532
NBP3-14094AF532
Alexa Fluor 594
NBP3-14094AF594
Alexa Fluor 647
NBP3-14094AF647
Alexa Fluor 700
NBP3-14094AF700
Alexa Fluor 750
NBP3-14094AF750
Allophycocyanin
NBP3-14094APC
Biotin
NBP3-14094B
CoraFluor 1
NBP3-14094CL1
DyLight 350
NBP3-14094UV
DyLight 405
NBP3-14094V
DyLight 488
NBP3-14094G
DyLight 550
NBP3-14094R
DyLight 594
NBP3-14094DL594
DyLight 650
NBP3-14094C
DyLight 680
NBP3-14094FR
DyLight 755
NBP3-14094IR
FITC
NBP3-14094F
HRP
NBP3-14094H
Janelia Fluor 525
NBP3-14094JF525
Janelia Fluor 549
NBP3-14094JF549
Janelia Fluor 585
NBP3-14094JF585
Janelia Fluor 635
NBP3-14094JF635
Janelia Fluor 646
NBP3-14094JF646
Janelia Fluor 669
NBP3-14094JF669
PE
NBP3-14094PE
PerCP
NBP3-14094PCP
mFluor Violet 450 SE
NBP3-14094MFV450
mFluor Violet 500 SE
NBP3-14094MFV500
mFluor Violet 610 SE
NBP3-14094MFV610
View Available Formulations
Catalog# & Formulation Size Price
Azide and BSA Free
NBP3-14094
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IGF-I R/IGF1R Antibody (IGF1R/4667) Summary

Description
200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-14094)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Non-hazardous.

Theoretical molecular weight: 130kDa (IGF-1R); 97kDa (IGF-1R); 200kDa (pro-IGF-1R)
Immunogen
Recombinant fragment (around aa550-750) of human IGF-I R/IGF1R protein (exact sequence is proprietary) (Uniprot: P08069)
Localization
Cell membrane
Isotype
IgG2c Kappa
Clonality
Monoclonal
Host
Mouse
Gene
IGF1R
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 1-2 ug/million cells
  • Immunocytochemistry/ Immunofluorescence 1-4 ug/ml
  • Immunohistochemistry-Paraffin
  • In vitro assay
  • Protein Array
Application Notes
In-vitro Neutralization of Biological Activity of IGF-1: Order Ab without Azide

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10 mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for IGF-I R/IGF1R Antibody (IGF1R/4667)

  • CD221 antigen
  • CD221
  • EC 2.7.10
  • EC 2.7.10.1
  • IGF1R
  • IGF-1R
  • IGF-I R
  • IGF-I receptor
  • IGFIR
  • IGF-IR
  • IGFR
  • insulin-like growth factor 1 receptor
  • Insulin-like growth factor I receptor
  • JTK13
  • MGC142170
  • MGC142172
  • MGC18216
  • soluble IGF1R variant 1
  • soluble IGF1R variant 2

Background

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IGF1R
Uniprot