IFN-gamma Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma, IFNG), also known as type II or Immune Interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa molecular weight variably glycosylated subunits. Glycosylation of IFN-gamma at sites Asn25 and Asn97 is critical for protease resistance. It shares 90% amino acid (aa) sequence identity with rhesus IFN-gamma, 59-64% with bovine, canine, equine, feline, and porcine IFN‑ gamma, and 37-43% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 7 applications: Array Development, ELISA Detection, ELISA Development, ELISA Development (Detection), ICC, IHC-Fr, Luminex Development.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using BAF285	Applications	Species
Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Natalie Tsubamoto, Miyako Noguchi, Jami McLaughlin et al. Defining T cell receptor repertoires using nanovial-based affinity and functional screening bioRxiv 6/15/2023 [PMID: 36711524]
A Titov, R Shaykhutdi, OV Shcherbako, YV Serdyuk, SA Sheetikov, KV Zornikova, AV Maleeva, A Khmelevska, DV Dianov, NT Shakirova, DB Malko, M Shkurnikov, S Nersisyan, A Tonevitsky, E Khamaganov, AV Ershov, EY Osipova, RV Nikolaev, DE Pershin, VA Vedmedskia, M Maschan, VR Ginanova, GA Efimov Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2 JCI Insight, 2022-05-09;7(9):. 2022-05-09 [PMID: 35389886] (ELISA Detection, Human)	ELISA Detection	Human
A Stumpf, T Brandstett, J Hübner, J Rühe Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum PLoS ONE, 2019-12-02;14(12):e0225525. 2019-12-02 [PMID: 31790441] (ELISA Detection, Human)	ELISA Detection	Human
J Hrdý, K Vlasáková, V ?erný, L Súkeníková, O Novotná, P Petrásková, K Boráková, R Lodinová-Ž, L Kolá?ová, L Prokešová Decreased allergy incidence in children supplemented with E. coli O83:K24:H31 and its possible modes of action Eur. J. Immunol., 2018-10-21;0(0):. 2018-10-21 [PMID: 30306557] (Human)		Human
E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma PLoS ONE, 2017-04-14;12(4):e0175712. 2017-04-14 [PMID: 28410380] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Erik M. Alcantar-Orozco, Hannah Gornall, Vania Baldan, Robert E. Hawkins, David E. Gilham Potential Limitations of the NSG Humanized Mouse as a Model System to Optimize Engineered Human T cell Therapy for Cancer Human Gene Therapy Methods 10/1/2013 [PMID: 23931270]
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (Luminex Development, Human)	Luminex Development	Human
Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin. Chem., 2007-11-01;53(11):2010-2. 2007-11-01 [PMID: 18030696] (ELISA Development, Human)	ELISA Development	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (Luminex Development, Human)	Luminex Development	Human
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (Luminex Development, Human)	Luminex Development	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (Luminex Development, Human)	Luminex Development	Human
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 2006-06-16;120(2):220-31. 2006-06-16 [PMID: 16782408] (ELISA Development, Human)	ELISA Development	Human
Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur. J. Neurosci., 2004-12-01;20(12):3222-32. 2004-12-01 [PMID: 15610155] (ICC, IHC-Fr, Human)	ICC, IHC-Fr	Human
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (Array Development, Human)	Array Development	Human
Laurent Brossay, Mariacristina Chioda, Nicolas Burdin, Yasuhiko Koezuka, Giulia Casorati, Paolo Dellabona et al. CD1d-mediated Recognition of an alpha -Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution J. Exp. Med 10/19/1998 [PMID: 9782129]
Show All 15 Publications. Collapse Publications.

Array BAF285

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes