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ICOS Antibody (ISA-3) [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, IP
Clone
ISA-3
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

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Catalog# & Conjugate Size Price
Alexa Fluor 750
NBP1-43126AF750
DyLight 680
NBP1-43126FR
Unconjugated
NBP1-43126-0.1mg
mFluor Violet 450 SE
NBP1-43126MFV450
mFluor Violet 500 SE
NBP1-43126MFV500
mFluor Violet 610 SE
NBP1-43126MFV610
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Catalog# & Formulation Size Price
Standard Formulation
NBP1-43126-0.1mg
BSA Free
NBP1-43126-0.1mg
BSA Free
NBP1-43126-0.025mg
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ICOS Antibody (ISA-3) [Biotin] Summary

Immunogen
The immunogen for this antibody was ICOS.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ICOS
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunoprecipitation
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for ICOS Antibody (ISA-3) [Biotin]

  • Activation-inducible lymphocyte immunomediatory molecule
  • AILIM
  • AILIMCD278
  • CD278 antigen
  • CD278
  • CRP-1
  • CVID1
  • ICOS
  • inducible costimulator
  • inducible T-cell costimulator
  • inducible T-cell co-stimulator
  • MGC39850

Background

The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ICOS