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ICOS Antibody (669230) [Allophycocyanin/Cy7]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
669230
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin/Cy7

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
MAB69751AF350
Alexa Fluor 405
MAB69751AF405
Alexa Fluor 488
MAB69751AF488
Alexa Fluor 532
MAB69751AF532
Alexa Fluor 594
MAB69751AF594
Alexa Fluor 647
MAB69751AF647
Alexa Fluor 700
MAB69751AF700
Alexa Fluor 750
MAB69751AF750
Allophycocyanin
MAB69751APC
Biotin
MAB69751B
DyLight 350
MAB69751UV
DyLight 405
MAB69751V
DyLight 488
MAB69751G
DyLight 550
MAB69751R
DyLight 594
MAB69751DL594
DyLight 650
MAB69751C
DyLight 680
MAB69751FR
DyLight 755
MAB69751IR
FITC
MAB69751F
Janelia Fluor 549
MAB69751JF549
Janelia Fluor 646
MAB69751JF646
PE
MAB69751PE
PE/Atto594
MAB69751PEATT594
PE/Cy5.5
MAB69751PECY55
PE/Cy7
MAB69751PECY7
PerCP
MAB69751PCP
Unconjugated
MAB69751
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB69751
Azide and BSA Free
MAB69751
Azide and BSA Free
MAB69751-SP
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ICOS Antibody (669230) [Allophycocyanin/Cy7] Summary

Immunogen
Partial recombinant human ICOS protein (amino acids 21-141) [UniProt Q9Y6W8]
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ICOS
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for ICOS Antibody (669230) [Allophycocyanin/Cy7]

  • Activation-inducible lymphocyte immunomediatory molecule
  • AILIM
  • AILIMCD278
  • CD278 antigen
  • CD278
  • CRP-1
  • CVID1
  • ICOS
  • inducible costimulator
  • inducible T-cell costimulator
  • inducible T-cell co-stimulator
  • MGC39850

Background

The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ICOS