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ICOS Antibody (669214) [DyLight 350]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, B/N
Clone
669214
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 350

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB69753U-100UG
Alexa Fluor 405
FAB69753V-100UG
Alexa Fluor 488
FAB69753G-100UG
Alexa Fluor 532
FAB69753X
Alexa Fluor 594
FAB69753T-100UG
Alexa Fluor 647
FAB69753R-100UG
Alexa Fluor 700
FAB69753N-100UG
Alexa Fluor 750
FAB69753S-100UG
Allophycocyanin
FAB69753A
Allophycocyanin/Cy7
FAB69753APCCY7
Biotin
FAB69753B
DyLight 405
FAB69753E
DyLight 488
FAB69753K
DyLight 550
FAB69753L
DyLight 594
FAB69753M
DyLight 650
FAB69753W
DyLight 680
FAB69753Y
DyLight 755
FAB69753Z
FITC
FAB69753F
HRP
FAB69753H
Janelia Fluor 549
FAB69753I
Janelia Fluor 646
FAB69753J
PE
FAB69753P
PE/Atto594
FAB69753PEATT594
PE/Cy5.5
FAB69753PECY55
PE/Cy7
FAB69753PECY7
PerCP
FAB69753C
Unconjugated
MAB69753-100
mFluor Violet 450 SE
FAB69753MFV450
mFluor Violet 500 SE
FAB69753MFV500
mFluor Violet 610 SE
FAB69753MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB69753-100
Carrier Free
FAB69753V-100UG
Carrier Free
FAB69753U-100UG
Carrier Free
FAB69753T-100UG
Carrier Free
FAB69753S-100UG
Carrier Free
FAB69753R-100UG
Carrier Free
FAB69753N-100UG
Carrier Free
FAB69753G-100UG
Carrier Free
MAB69753-100
Carrier Free
MAB69753-SP
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ICOS Antibody (669214) [DyLight 350] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human ICOS and mouse myeloma cell line NS0-derived recombinant human ICOS cocktail
Glu21-Phe141
Accession # Q9Y6W8
Specificity
Detects human ICOS in direct ELISAs.
Isotype
IgG3
Clonality
Monoclonal
Host
Mouse
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • Blockade of Receptor-ligand Interaction
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for ICOS Antibody (669214) [DyLight 350]

  • Activation-inducible lymphocyte immunomediatory molecule
  • AILIM
  • AILIMCD278
  • CD278 antigen
  • CD278
  • CRP-1
  • CVID1
  • ICOS
  • inducible costimulator
  • inducible T-cell costimulator
  • inducible T-cell co-stimulator
  • MGC39850

Background

The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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