Human WIF-1 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

WIF-1 (Wnt Inhibitory Factor 1) is a secreted protein that binds to Wnt proteins and inhibits their activity. In situ hybridization analysis in Xenopus laevis and zebrafish indicate that the message is highly expressed in presomitic mesoderm, the notochord, anterior regions of the brain, branchial arches, nasal placodes, and otic vescicles. WIF-1 inhibits secondary axis induction by Wnts and promotes secondary axis induction by Chordin in Xenopus embryos. In vitro, WIF-1 binds to Drosophila Wingless and Xenopus Wnt8 proteins. WIF-1 is implicated as an early event tumor suppressor in cancers of the prostate, breast, lung, and bladder, while in other cancer types, such as colon adenocarcinoma, WIF-1 facilitates tumorigenesis. WIF-1 is also expressed in mammalian retina and may play a role in photoreceptor development. The protein is synthesized as a 379 amino acid (aa) molecule that contains a signal sequence, a 150 aa WIF domain, 5 EGF-like repeats, and a hydrophilic domain at the carboxy terminus.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 2 of 2.

Publications using DY134	Applications	Species
T Ueland, E Astrup, K Otterdal, T Lekva, J Janardhana, JAJ Prakash, K Thomas, AE Michelsen, P Aukrust, GM Varghese, JK Damås Secreted Wnt antagonists in scrub typhus PloS Neglected Tropical Diseases, 2021-04-29;15(4):e0009185. 2021-04-29 [PMID: 33914733] (Human)		Human
CB Chen, WC Chang, MY Wu, TY Kao, YW Wang, CW Wang, CJ Chen, WH Chung, SC Su Attenuation of Wnt/beta-catenin signaling in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis Int. J. Biol. Sci., 2020-01-01;16(2):353-364. 2020-01-01 [PMID: 31929762] (Human)		Human

Array DY134

• WIF-1 Antibodies
• WIF-1 Lysate
• WIF-1 Proteins and Enzymes
• WIF-1 ELISA