Human TIMP-4 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 4 of 4.

Publications using DY974	Applications	Species
MM Brunton-O', AS Holley, KE Hally, GA Kristono, SA Harding, PD Larsen A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction Scientific Reports, 2021-06-16;11(1):12705. 2021-06-16 [PMID: 34135421] (Human)		Human
Drewlo S, Czikk M, Baczyk D, Lye S, Kingdom J Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi. Hum. Reprod., 2011-03-15;26(5):1025-34. 2011-03-15 [PMID: 21406447] (Human)		Human
Tsai HC, Ye SY, Kunin CM, Lee SS, Wann SR, Tai MH, Shi MH, Liu YC, Chen YS Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis. Cytokine, 2011-02-26;54(0):109-16. 2011-02-26 [PMID: 21354815] (Human)		Human
Tsai HC, Chung LY, Chen ER, Sy CL Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am. J. Trop. Med. Hyg., 2008-01-01;78(1):20-7. 2008-01-01 [PMID: 18187780] (Human)		Human

Array DY974

• TIMP-4 Antibodies
• TIMP-4 ELISA Kits
• TIMP-4 Lysate
• TIMP-4 ELISAs
• TIMP-4 Proteins and Enzymes