Human Phospho-IGF-I R/IGF1R DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.

IGF-II R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF-II R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF-II biology, It would appear that IGF-II R is principally a regulator of local IGF-II levels, targeting IGF-II for destruction in lysosomes.

The heterotetrameric receptors for insulin (INS R) and IGF-I (IGF-I R) are receptor tyrosine kinases that consist of two ligandbinding alpha subunits and two beta subunits. Ligand binding induces autophosphorylation on multiple tyrosine residues of beta subunits. Phosphorylation of Tyr1162 and 1163 on INS R and Tyr1135 and 1136 on IGF-I R stimulates intrinsic kinase activity.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 6 of 6.

Publications using DYC1770-2	Applications	Species
Hjortebjerg, R;Høgdall, C;Hansen, KH;Høgdall, E;Frystyk, J; The IGF-PAPP-A-Stanniocalcin Axis in Serum and Ascites Associates with Prognosis in Patients with Ovarian Cancer International journal of molecular sciences 2024-02-07 [PMID: 38396692] (Human)		Human
G Vaniotis, S Moffett, T Sulea, N Wang, SM Elahi, E Lessard, J Baardsnes, S Perrino, Y Durocher, J Frystyk, B Massie, P Brodt Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties Sci Rep, 2018-11-26;8(1):17361. 2018-11-26 [PMID: 30478273] (Human)		Human
Brouwer-Visser , Jurriaan, Lee , Jiyeon, McCullagh , KellyAnn, Cossio , Maria J, Wang , Yanhua, Huang , Gloria S Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. PLoS ONE, 2014-06-16;9(6):e100165. 2014-06-16 [PMID: 24932685] (Human)		Human
Banerjee J, Das Ghatak P, Roy S, Khanna S, Sequin E, Bellman K, Dickinson B, Suri P, Subramaniam V, Chang C, Sen C Improvement of human keratinocyte migration by a redox active bioelectric dressing. PLoS ONE, 2014-03-03;9(3):e89239. 2014-03-03 [PMID: 24595050] (Human)		Human
Reinhard M, Frystyk J, Jespersen B, Bjerre M, Christiansen J, Flyvbjerg A, Ivarsen P Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study. BMC Nephrol, 2013-04-04;14(0):80. 2013-04-04 [PMID: 23557110] (Human)		Human
O'Brien NA, Browne BC, Chow L, Wang Y, Ginther C, Arboleda J, Duffy MJ, Crown J, O'Donovan N, Slamon DJ Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol. Cancer Ther., 2010-05-25;9(6):1489-502. 2010-05-25 [PMID: 20501798] (Human)		Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Patricia Carulla Martí			06/22/2023	View Summary Sample Tested Cell lysate from Human Keratinocytes (Hacat) in presence or absence of IGF,Cultured Human Keratinocytes Lot P307442

Array DYC1770-2

• IGF-I R/IGF1R Antibodies
• IGF-I R/IGF1R ELISA Kits
• IGF-I R/IGF1R Lysate
• IGF-I R/IGF1R Proteins
• IGF-I R/IGF1R Proteins and Enzymes
• IGF-I R/IGF1R ELISAs