Human/Mouse Total COX-2 DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using DYC4198-2	Applications	Species
Chae, S;Lee, HJ;Lee, HE;Kim, J;Jeong, YJ;Lin, Y;Kim, HY;Leriche, G;Ehrlich, RS;Lingl, SC;Seo, MD;Lee, YH;Yang, J;Kim, JI;Hoe, HS; The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta Journal of neuroinflammation 2024-08-11 [PMID: 39129007] (Mouse)		Mouse
Kaplan, HM;Deger, M;Erdogan, KE;Ates, T;Demir, E; Alpha-linolenic acid protects against methotrexate-induced nephrotoxicity in mouse kidney cells European review for medical and pharmacological sciences 2023-11-01 [PMID: 38039041] (Mouse)		Mouse
Rahman, M;Upadhyay, S;Ganguly, K;Introna, M;Ji, J;Boman, C;Muala, A;Blomberg, A;Sandström, T;Palmberg, L; Comparable Response Following Exposure to Biodiesel and Diesel Exhaust Particles in Advanced Multicellular Human Lung Models Toxics 2023-06-14 [PMID: 37368632] (Human)		Human
J Kim, SG Jeon, HR Jeong, H Park, JI Kim, HS Hoe L-Type Ca2+ Channel Inhibition Rescues the LPS-Induced Neuroinflammatory Response and Impairments in Spatial Memory and Dendritic Spine Formation International Journal of Molecular Sciences, 2022-11-06;23(21):. 2022-11-06 [PMID: 36362394] (Mouse)		Mouse
B Eggers, MB Stope, J Marciniak, A Mustea, J Deschner, M Nokhbehsai, FJ Kramer Modulation of Inflammatory Responses by a Non-Invasive Physical Plasma Jet during Gingival Wound Healing Cells, 2022-09-02;11(17):. 2022-09-02 [PMID: 36078148] (Human)		Human
J Kim, HJ Lee, JH Park, BY Cha, HS Hoe Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling Journal of Neuroinflammation, 2022-07-15;19(1):187. 2022-07-15 [PMID: 35841100] (Mouse)		Mouse
S Yoshida, H Inaba, R Nomura, K Nakano, M Matsumoto- Green tea catechins inhibit Porphyromonas gulae LPS-induced inflammatory responses in human gingival epithelial cells: Running title Journal of oral biosciences, 2022-06-02;0(0):. 2022-06-02 [PMID: 35660639] (Human)		Human
G Wang, X Li, N Li, X Wang, S He, W Li, W Fan, R Li, J Liu, S Hou Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization Redox Biology, 2022-03-18;52(0):102297. 2022-03-18 [PMID: 35334248] (Human)		Human
JH Liu, CH Hsieh, CY Liu, CW Chang, YJ Chen, TH Tsai Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice Journal of ethnopharmacology, 2021-02-07;271(0):113912. 2021-02-07 [PMID: 33567307] (Mouse)		Mouse
AVB Nogueira, M Nokhbehsai, A Damanaki, S Eick, C Kirschneck, A Schröder, J Jantsch, J Deschner Filifactor alocis and Tumor Necrosis Factor-Alpha Stimulate Synthesis of Visfatin by Human Macrophages International Journal of Molecular Sciences, 2021-01-27;22(3):. 2021-01-27 [PMID: 33513808] (Human)		Human
R Nomura, H Inaba, H Yasuda, M Shirai, Y Kato, M Murakami, N Iwashita, S Shirahata, S Yoshida, S Matayoshi, J Yasuda, N Arai, F Asai, M Matsumoto-, K Nakano Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha Sci Rep, 2020-02-20;10(1):3113. 2020-02-20 [PMID: 32080231] (Human)		Human
CT Hsieh, YJ Lee, X Dai, NB Ojeda, HJ Lee, LT Tien, LW Fan Systemic Lipopolysaccharide-Induced Pain Sensitivity and Spinal Inflammation Were Reduced by Minocycline in Neonatal Rats Int J Mol Sci, 2018-09-27;19(10):. 2018-09-27 [PMID: 30262747] (Rat)		Rat
XJ Ma, HZ Xing, GF Ren, XJ Rao, ZZ Li JIP3 knockout protects mice against high fat diet-induced liver injury Biochem. Biophys. Res. Commun., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454969] (Mouse)		Mouse
SH Kim, HJ Choi, WK Yang, JE Lee, JH Cho, IJ Park, S Park, BK Park, M Jin Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats Evid Based Complement Alternat Med, 2017-08-22;2017(0):1791403. 2017-08-22 [PMID: 28904551] (Rat)		Rat
H Wu, Z Yin, L Wang, F Li, Y Qiu Honokiol improved chondrogenesis and suppressed inflammation in human umbilical cord derived mesenchymal stem cells via blocking nuclear factor-?B pathway BMC Cell Biol., 2017-08-29;18(1):29. 2017-08-29 [PMID: 28851291] (Human)		Human
SR Burks, BA Nguyen, MN Bresler, ME Nagle, SJ Kim, JA Frank Anti-inflammatory drugs suppress ultrasound-mediated mesenchymal stromal cell tropism to kidneys Sci Rep, 2017-08-17;7(1):8607. 2017-08-17 [PMID: 28819122] (Mouse)		Mouse
Jun Lu Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression Brain Res. Bull, 2016-11-30;0(0):. 2016-11-30 [PMID: 27915092] (Rat)		Rat
Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain J Neuroinflammation, 2016-11-08;13(1):286. 2016-11-08 [PMID: 27821173] (Mouse)		Mouse
Zhang Z, Chen N, Liu J, Wu J, Zhang J, Zhang Y, Jiang X Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway. Mol Med Rep, 2014-05-09;10(1):101-6. 2014-05-09 [PMID: 24818579] (Mouse)		Mouse
Show All 19 Publications. Collapse Publications.

Array DYC4198-2

• COX-2 Antibodies
• COX-2 Protein
• COX-2 Proteins and Enzyme
• COX-2 ELISA