Human IL-15 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-15 (Interleukin 15) is a cytokine that induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells. It also induces dendritic cell differentiation and inflammatory activation, exhibits anti-tumor activity, and inhibits the deposition of lipid in adipocytes. Complexes of IL-15 with cell surface IL-15 R alpha interact with complexes of IL-2 R beta and the Common gamma Chain on adjacent cells. This transpresentation mechanism enables cells to respond to IL-15 even if they do not express IL-15 R alpha. Ligation of membrane-associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells. The activity of circulating IL-15 is limited by its association with soluble IL-15 R alpha.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using DY247	Applications	Species
Fiorillo, A;Gallego, JJ;Casanova-Ferrer, F;Giménez-Garzó, C;Urios, A;Ballester, MP;Durbán, L;Rios, MP;Megías, J;San Miguel, T;Kosenko, E;Escudero-García, D;Benlloch, S;Felipo, V;Montoliu, C; Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease International journal of molecular sciences 2023-06-20 [PMID: 37373554] (Human)		Human
P Bajgain, AG Torres Cha, K Balasubram, L Fleckenste, P Lulla, HE Heslop, J Vera, AM Leen Secreted Fas decoys enhance the antitumor activity of engineered and bystander T cells in Fas ligand-expressing solid tumors Oncogene, 2022-11-02;0(0):. 2022-11-02 [PMID: 36122411] (Human)		Human
T Bellón, O González-V, E Sendagorta, V Lerma, J Martínez D, C Martínez, G Servera, C González-H, L Cachafeiro, JA Lorente, R Cabañas, P Herranz, F de Abajo, PIELenRed IL-15/IL-15Ralpha in SJS/TEN: Relevant Expression of IL15 and IL15RA in Affected Skin Biomedicines, 2022-08-02;10(8):. 2022-08-02 [PMID: 36009415] (Human)		Human
A Rosewell S, C Porter, G Biegert, L Jatta, M Suzuki HydrAd: A Helper-Dependent Adenovirus Targeting Multiple Immune Pathways for Cancer Immunotherapy Oncogene, 2022-06-02;14(11):. 2022-06-02 [PMID: 35681750] (Human)		Human
LA Leroy, A Mac Donald, A Kandlur, D Bose, P Xiao, J Gagnon, F Villinger, Y Chebloune Cytokine Adjuvants IL-7 and IL-15 Improve Humoral Responses of a SHIV LentiDNA Vaccine in Animal Models Vaccines, 2022-03-17;10(3):. 2022-03-17 [PMID: 35335093] (Human)		Human
AK Singh, N Kasarpalka, S Bhowmick, G Paradkar, M Talreja, K Shah, A Tiwari, H Palav, S Kaginkar, R Kulkarni, A Patil, V Kalsurkar, S Agrawal, J Shastri, R Dere, R Bharmal, SD Mahale, VM Bhor, V Patel Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology Journal of leukocyte biology, 2022-01-24;0(0):. 2022-01-24 [PMID: 35075682] (Human)		Human
GR Kathamuthu, K Moideen, R Sridhar, D Baskaran, S Babu Altered plasma levels of &betaC and &gammaC chain cytokines and post-treatment modulation in tuberculous lymphadenitis Cytokine, 2020-12-17;138(0):155405. 2020-12-17 [PMID: 33341600] (Human)		Human
A Suhail, ZA Rizvi, P Mujagond, SA Ali, P Gaur, M Singh, V Ahuja, A Awasthi, CV Srikanth DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells Cell Rep, 2019-12-10;29(11):3522-3538.e7. 2019-12-10 [PMID: 31825833] (Human)		Human
Ewa Kuca-Warna, Weronika Kurowska, Monika Prochorec, Anna Radzikows, Tomasz Burakowsk, Urszula Skalska, Magdalena Massalska, Magdalena Pleba?czy, Barbara Ma?dyk-No, Iwona S?owi?ska, Robert Gasik, W?odzimierz Ma?li?ski Rheumatoid arthritis bone marrow environment supports Th17 response. Arthritis Research & Therapy, 2017-12-08;0(0):1478-6362. 2017-12-08 [PMID: 29216915] (Human)		Human
Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways. J Immunol, 2015-08-14;195(6):2818-28. 2015-08-14 [PMID: 26276870] (Human)		Human
Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res, 2014-06-30;74(17):4908-21. 2014-06-30 [PMID: 24980552] (Human)		Human
Barra NG, Reid S, MacKenzie R Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes. Obesity (Silver Spring), 2009-12-17;18(8):1601-7. 2009-12-17 [PMID: 20019685] (Human)		Human
Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin. Exp. Immunol., 2008-11-26;155(2):266-74. 2008-11-26 [PMID: 19040600] (Human)		Human
Duitman EH, Orinska Z, Bulanova E, Paus R, Bulfone-Paus S How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol. Cell. Biol., 2008-05-27;28(15):4851-61. 2008-05-27 [PMID: 18505820] (Human)		Human
Monti P, Scirpoli M, Maffi P, Ghidoli N, De Taddeo F, Bertuzzi F, Piemonti L, Falcone M, Secchi A, Bonifacio E Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J. Clin. Invest., 2008-05-01;118(5):1806-14. 2008-05-01 [PMID: 18431516] (Human)		Human
Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15. J. Biol. Chem., 2007-02-27;282(18):13167-79. 2007-02-27 [PMID: 17327231] (Human)		Human
Miranda-Carus ME, Benito-Miguel M, Llamas MA, Balsa A, Martin-Mola E Human T cells constitutively express IL-15 that promotes ex vivo T cell homeostatic proliferation through autocrine/juxtacrine loops. J. Immunol., 2005-09-15;175(6):3656-62. 2005-09-15 [PMID: 16148110] (Human)		Human
Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J. Immunol., 2004-07-15;173(2):1463-76. 2004-07-15 [PMID: 15240743] (Human)		Human
Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A., 2003-07-23;100(16):9452-7. 2003-07-23 [PMID: 12878725] (Human)		Human
Show All 19 Publications. Collapse Publications.

Array DY247

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes