Human IL-11 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using DY218	Applications	Species
Singh, A;Cho, WJ;Pulimamidi, VK;Mittal, SK;Chauhan, SK; Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing Investigative ophthalmology & visual science 2023-11-01 [PMID: 37910094] (Mouse)		Mouse
MG Connor, TMN Camarasa, E Patey, O Rasid, L Barrio, CM Weight, DP Miller, RS Heyderman, RJ Lamont, J Enninga, MA Hamon The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae Nature Microbiology, 2020-12-21;0(0):. 2020-12-21 [PMID: 33349663] (Human)		Human
Z Kargarpour, J Nasirzade, L Panahipour, RJ Miron, R Gruber Relative Centrifugal Force (RCF; G-Force) Affects the Distribution of TGF-&beta in PRF Membranes Produced Using Horizontal Centrifugation Int J Mol Sci, 2020-10-15;21(20):. 2020-10-15 [PMID: 33076376] (Human)		Human
S Alarifi, S Alkahtani, AA Al-Qahtani, C Stournaras, G Sourvinos Induction of interleukin-11 mediated by RhoA GTPase during human cytomegalovirus lytic infection Cell. Signal., 2020-03-09;70(0):109599. 2020-03-09 [PMID: 32165237] (Human)		Human
D Brünnert, I Shekhawat, KR Chahar, J Ehrhardt, J Pandey, JK Yadav, M Zygmunt, P Goyal Thrombin stimulates gene expression and secretion of IL-11 via protease-activated receptor-1 and regulates extravillous trophoblast cell migration J. Reprod. Immunol., 2019-03-09;132(0):35-41. 2019-03-09 [PMID: 30903857] (Human)		Human
KLR Gustafsson, T Renné, C Söderberg-, LM Butler Human cytomegalovirus replication induces endothelial cell interleukin-11 Cytokine, 2018-05-25;0(0):. 2018-05-25 [PMID: 29807687] (Human)		Human
S Elbitar, D Susan-Resi, Y Ghaleb, P El Khoury, G Peloso, N Stitziel, JP Rabès, V Carreau, J Hamelin, A Ben-Djoudi, E Bruckert, C Boileau, NG Seidah, M Varret, M Abifadel New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia Sci Rep, 2018-01-31;8(1):1943. 2018-01-31 [PMID: 29386597] (Human)		Human
Hoffmann F, Hofereiter J, Rubsamen H, Melms J, Schwarz S, Faber H, Weber P, Putz B, Loleit V, Weber F, Hohlfeld R, Meinl E, Krumbholz M Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation, 2015-09-30;12(0):184. 2015-09-30 [PMID: 26419927] (Human)		Human
Zhang X, Tao Y, Chopra M, Ahn M, Marcus K, Choudhary N, Zhu H, Markovic-Plese S Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. J Immunol, 2013-11-06;191(12):5867-74. 2013-11-06 [PMID: 24198283] (Human)		Human
Ramani V, Sanderson R Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse. Matrix Biol, 2013-10-18;35(0):215-22. 2013-10-18 [PMID: 24145151] (Human)		Human
Pollari S, Leivonen SK, Perälä M, Fey V, Kakonen SM, Kallioniemi O Identification of microRNAs inhibiting TGF-beta-induced IL-11 production in bone metastatic breast cancer cells. PLoS ONE, 2012-05-21;7(5):e37361. 2012-05-21 [PMID: 22629385] (Human)		Human
Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol, 2011-12-21;5(2):140-9. 2011-12-21 [PMID: 22189956] (Human)		Human
Ramani VC, Yang Y, Ren Y Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity. J. Biol. Chem., 2010-12-03;286(8):6490-9. 2010-12-03 [PMID: 21131364] (Human)		Human
Potapova IA, Gaudette GR, Brink PR, Robinson RB, Rosen MR, Cohen IS, Doronin SV Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells, 2007-03-29;25(7):1761-8. 2007-03-29 [PMID: 17395769] (Human)		Human
Show All 14 Publications. Collapse Publications.

Array DY218

• IL-11 Antibodies
• IL-11 ELISA Kits
• IL-11 Lysate
• IL-11 Proteins
• IL-11 Proteins and Enzymes
• IL-11 ELISAs