Human Dkk-1 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using DKK100B	Applications	Species
T Shi, Y Zhang, Y Wang, X Song, H Wang, X Zhou, K Liang, Y Luo, K Che, X Wang, Y Pan, F Liu, J Yang, Q Liu, L Yu, B Liu, J Wei DKK1 promotes tumor immune evasion and impedes anti-PD-1 treatment by inducing immunosuppressive macrophages in gastric cancer Cancer Immunology Research, 2022-12-02;0(0):. 2022-12-02 [PMID: 36206576] (Human)		Human
C Papagoras, S Tsiami, A Chrysantho, I Mitroulis, X Baraliakos Serum granulocyte-macrophage colony-stimulating factor (GM-CSF) is increased in patients with active radiographic axial spondyloarthritis and persists despite anti-TNF treatment Arthritis Research & Therapy, 2022-08-16;24(1):195. 2022-08-16 [PMID: 35974380] (Human)		Human
T Suda, T Yamashita, H Sunagozaka, H Okada, K Nio, Y Sakai, T Yamashita, E Mizukoshi, M Honda, S Kaneko Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma International Journal of Molecular Sciences, 2022-03-03;23(5):. 2022-03-03 [PMID: 35269944] (Human)		Human
YH Jung, CW Chae, GE Choi, HC Shin, JR Lim, HS Chang, J Park, JH Cho, MR Park, HJ Lee, HJ Han Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts Journal of Biomedical Science, 2022-03-07;29(1):17. 2022-03-07 [PMID: 35255899] (Human)		Human
L Kobari, M Auclair, O Piau, N Ferrand, M Zaoui, F Delhommeau, B Fève, M Sabbah, L Garderet Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells Leukemia, 2021-09-23;0(0):. 2021-09-23 [PMID: 34556797] (Human)		Human
CA Nava-Valdi, JM Ponce-Guar, AM Saldaña-Cr, EG Corona-San, M Ramirez-Vi, EE Perez-Guer, JD Murillo-Sa, B Contreras-, ML Vazquez-Vi, F Gonzalez-P, D Bonilla-La, H Jacobo-Cue, JD Centeno-Va, G Echeverria, S Cerpa-Cruz, MF Alcaraz-Lo, EG Cardona-Mu, M Salazar-Pa, L Gonzalez-L, JI Gamez-Nava Assessment of Serum sRANKL, sRANKL/OPG Ratio, and Other Bone Turnover Markers with the Estimated 10-Year Risk of Major and Hip Osteoporotic Fractures in Rheumatoid Arthritis: A Cross-Sectional Study BioMed Research International, 2021-08-30;2021(0):5567666. 2021-08-30 [PMID: 34497849] (Human)		Human
E Galliera, L Massaccesi, E de Benedet, E Longhi, D de Toma, MM Corsi Roma, G Banfi Longitudinal evaluation of Wnt inhibitors and comparison with others serum osteoimmunological biomarkers in osteolytic bone metastasis J. Leukoc. Biol., 2020-02-07;0(0):. 2020-02-07 [PMID: 32034807] (Human)		Human
M Diani, S Perego, V Sansoni, L Bertino, M Gomarasca, M Faraldi, PDM Pigatto, G Damiani, G Banfi, G Altomare, G Lombardi Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients Int J Mol Sci, 2019-11-10;20(22):. 2019-11-10 [PMID: 31717649] (Human)		Human
S Mihai, E Codrici, ID Popescu, AM Enciu, E Rusu, D Zilisteanu, LG Necula, G Anton, C Tanase Inflammation-Related Patterns in the Clinical Staging and Severity Assessment of Chronic Kidney Disease Dis. Markers, 2019-10-07;2019(0):1814304. 2019-10-07 [PMID: 31687048] (Human)		Human
C Mambet, L Necula, S Mihai, L Matei, C Bleotu, M Chivu-Econ, O Stanca, A Tatic, N Berbec, C Tanase, CC Diaconu Increased Dkk-1 plasma levels may discriminate disease subtypes in myeloproliferative neoplasms J. Cell. Mol. Med., 2018-07-05;0(0):. 2018-07-05 [PMID: 29975001] (Human)		Human
DR Jadon, R Sengupta, A Nightingal, H Lu, J Dunphy, A Green, JT Elder, RP Nair, E Korendowyc, MA Lindsay, NJ McHugh Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study Arthritis Res. Ther., 2017-09-21;19(1):210. 2017-09-21 [PMID: 28934972] (Human)		Human
X Tang, J Lin, G Wang, J Lu MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression PLoS ONE, 2017-06-19;12(6):e0179860. 2017-06-19 [PMID: 28628652] (Rat)		Rat
TH Kim, JS Chang, KS Park, J Park, N Kim, JI Lee, ID Kong Effects of exercise training on circulating levels of Dickkpof-1 and secreted frizzled-related protein-1 in breast cancer survivors: A pilot single-blind randomized controlled trial PLoS ONE, 2017-02-08;12(2):e0171771. 2017-02-08 [PMID: 28178355] (Human)		Human
CC Niu, SS Lin, LJ Yuan, LH Chen, CY Yang, AN Chung, ML Lu, TT Tsai, PL Lai, WJ Chen Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL BMC Musculoskelet Disord, 2017-02-02;18(1):61. 2017-02-02 [PMID: 28153008] (Human)		Human
EJ Lee, SM Kim, B Choi, EY Kim, YH Chung, EJ Lee, B Yoo, CK Lee, S Hong, BJ Kim, JM Koh, SH Kim, YG Kim, EJ Chang Interleukin-32 Gamma Stimulates Bone Formation by Increasing miR-29a in Osteoblastic Cells and Prevents the Development of Osteoporosis Sci Rep, 2017-01-12;7(0):40240. 2017-01-12 [PMID: 28079119] (Human)		Human
Hartman M, Talar B, Noman M, Gajos-Michniewicz A, Chouaib S, Czyz M Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype. PLoS ONE, 2014-04-14;9(4):e95157. 2014-04-14 [PMID: 24733089] (Human)		Human
Andre T, Meuleman N, Stamatopoulos B, De Bruyn C, Pieters K, Bron D, Lagneaux L Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells. PLoS ONE, 2013-03-21;8(3):e59756. 2013-03-21 [PMID: 23555770] (Human)		Human
Scheel C, Eaton E, Li S, Chaffer C, Reinhardt F, Kah K, Bell G, Guo W, Rubin J, Richardson A, Weinberg R Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell, 2011-06-10;145(6):926-40. 2011-06-10 [PMID: 21663795] (Human)		Human
Gunn WG, Krause U, Lee N, Gregory CA Pharmaceutical inhibition of glycogen synthetase kinase-3beta reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model. Blood, 2010-12-01;117(5):1641-51. 2010-12-01 [PMID: 21123822] (Mouse)		Mouse
Honsawek S, Tanavalee A, Yuktanandana P, Ngarmukos S, Saetan N, Tantavisut S Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients. BMC Musculoskelet Disord, 2010-11-10;11(0):257. 2010-11-10 [PMID: 21062498] (Human)		Human
Olivares-Navarrete R, Hyzy S, Wieland M, Boyan BD, Schwartz Z The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces. Biomaterials, 2009-12-09;31(8):2015-24. 2009-12-09 [PMID: 20004015] (Human)		Human
Show All 21 Publications. Collapse Publications.

Array DKK100B

• Dkk-1 Antibodies
• Dkk-1 Antibody Pair
• Dkk-1 ELISA Kit
• Dkk-1 Lysate
• Dkk-1 Proteins and Enzymes
• Dkk-1 ELISAs