Human Dkk-1 DuoSet ELISA, 15 Plate

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Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using DY1906	Applications	Species
Inomata, Y;Kuroha, M;Shimoyama, Y;Naito, T;Moroi, R;Shiga, H;Kakuta, Y;Karasawa, H;Onuma, S;Kinouchi, Y;Masamune, A; Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis Cancer medicine 2024-01-01 [PMID: 38334454] (Human)		Human
M Dahlmann, A Monks, ED Harris, D Kobelt, M Osterland, F Khaireddin, P Herrmann, W Kemmner, S Burock, W Walther, RH Shoemaker, U Stein Combination of Wnt/beta-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal Cancer Cancers, 2021-12-22;14(1):. 2021-12-22 [PMID: 35008201] (Human)		Human
W Supsavhad, BB Hassan, JK Simmons, WP Dirksen, SM Elshafae, NA Kohart, AA Demirer, TJ Rosol Effect of Dickkopf-1 (Dkk-1) and SP600125, a JNK Inhibitor, on Wnt Signaling in Canine Prostate Cancer Growth and Bone Metastases Veterinary sciences, 2021-08-01;8(8):. 2021-08-01 [PMID: 34437475] (Human)		Human
YY Liu, SY Wang, YN Li, WJ Bian, LQ Zhang, YH Li, L Long, X Liu, XW Zhang, ZG Li Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA Chin. Med. J., 2020-03-20;0(6):679-686. 2020-03-20 [PMID: 32068606] (Human)		Human
O Lyros, AK Lamprecht, L Nie, R Thieme, K Götzel, M Gasparri, G Haasler, P Rafiee, R Shaker, I Gockel Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma Am J Cancer Res, 2019-02-01;9(2):330-346. 2019-02-01 [PMID: 30906632] (Human)		Human
EP McNeill, RW Reese, A Tondon, BH Clough, S Pan, J Froese, D Palmer, U Krause, DM Loeb, R Kaunas, CA Gregory Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition Cell Death Dis, 2018-11-26;9(12):1161. 2018-11-26 [PMID: 30478297] (Human)		Human
X Huang, JN Post, L Zhong, J Leijten, S Larsson, M Karperien, A Struglics Dickkopf-related protein 1 and Gremlin 1 show different response than Frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis Osteoarthr. Cartil., 2018-03-08;0(0):. 2018-03-08 [PMID: 29526783] (Human)		Human
EZ Hoseth, F Krull, I Dieset, RH Mørch, S Hope, ES Gardsjord, NE Steen, I Melle, HR Brattbakk, VM Steen, P Aukrust, S Djurovic, OA Andreassen, T Ueland Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder Transl Psychiatry, 2018-03-06;8(1):55. 2018-03-06 [PMID: 29507296] (Human)		Human
L Zhong, S Schivo, X Huang, J Leijten, M Karperien, JN Post Nitric Oxide Mediates Crosstalk between Interleukin 1? and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression Int J Mol Sci, 2017-11-22;18(11):. 2017-11-22 [PMID: 29165387] (Human)		Human
Nocturne G, Pavy S, Boudaoud S, Seror R, Goupille P, Chanson P, van der Heijde D, van Gaalen F, Berenbaum F, Mariette X, Briot K, Feydy A, Claudepierre P, Dieude P, Nithitham J, Taylor K, Criswell L, Dougados M, Roux C, Miceli-Richard C Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort. PLoS ONE, 2015-08-27;10(8):e0134974. 2015-08-27 [PMID: 26313358] (Human)		Human
Granchi D, Corrias MV, Garaventa A, Baglio SR, Cangemi G, Carlini B, Paolucci P, Giunti A, Baldini N Neuroblastoma and bone metastases: clinical significance and prognostic value of Dickkopf 1 plasma levels. Bone, 2010-07-14;48(1):152-9. 2010-07-14 [PMID: 20603237] (Human)		Human
Rodland EK, Ueland T, Pedersen TM, Halvorsen B, Muller F, Aukrust P, Froland SS Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis. Infect. Immun., 2009-12-14;78(3):1269-75. 2009-12-14 [PMID: 20008537] (Human)		Human
Koch S, Capaldo CT, Samarin S, Nava P, Neumaier I, Skerra A, Sacks DB, Parkos CA, Nusrat A Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol. Biol. Cell, 2009-09-23;20(22):4816-25. 2009-09-23 [PMID: 19776352] (Human)		Human
Korf-Klingebiel M, Kempf T, Sauer T, Brinkmann E, Fischer P, Meyer GP, Ganser A, Drexler H, Wollert KC Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction. Eur. Heart J., 2008-10-25;29(23):2851-8. 2008-10-25 [PMID: 18953051] (Human)		Human
Granchi D, Baglio SR, Amato I, Giunti A, Baldini N Paracrine inhibition of osteoblast differentiation induced by neuroblastoma cells. Int. J. Cancer, 2008-10-01;123(7):1526-35. 2008-10-01 [PMID: 18623132] (Human)		Human
Thudi NK, Martin CK, Nadella MV Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions. Prostate, 2008-07-01;68(10):1116-25. 2008-07-01 [PMID: 18461562] (Human)		Human
Raje N, Woo SB, Hande K, Yap JT, Richardson PG, Vallet S, Treister N, Hideshima T, Sheehy N, Chhetri S, Connell B, Xie W, Tai YT, Szot-Barnes A, Tian M, Schlossman RL, Weller E, Munshi NC, Van Den Abbeele AD, Anderson KC Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw. Clin. Cancer Res., 2008-04-15;14(8):2387-95. 2008-04-15 [PMID: 18413829] (Human)		Human
Lee N, Smolarz AJ, Olson S, David O, Reiser J, Kutner R, Daw NC, Prockop DJ, Horwitz EM, Gregory CA A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. Br. J. Cancer, 2007-11-06;97(11):1552-9. 2007-11-06 [PMID: 17987039] (Human)		Human
Garderet L, Mazurier C, Chapel A, Ernou I, Boutin L, Holy X, Gorin NC, Lopez M, Doucet C, Lataillade JJ Mesenchymal stem cell abnormalities in patients with multiple myeloma. Leuk. Lymphoma, 2007-10-01;48(10):2032-41. 2007-10-01 [PMID: 17917971] (Human)		Human
Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res., 2007-08-15;67(16):7665-74. 2007-08-15 [PMID: 17702698] (Human)		Human
Forget MA, Turcotte S, Beauseigle D, Godin-Ethier J, Pelletier S, Martin J, Tanguay S, Lapointe R The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types. Br. J. Cancer, 2007-01-23;96(4):646-53. 2007-01-23 [PMID: 17245340] (Human)		Human
Show All 21 Publications. Collapse Publications.

Array DY1906

• Dkk-1 Antibodies
• Dkk-1 Antibody Pair
• Dkk-1 ELISA Kit
• Dkk-1 Lysate
• Dkk-1 ELISAs
• Dkk-1 Proteins and Enzymes