Human CD47 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a ubiquitous transmembrane protein that binds to SIRP family members on macrophages, neutrophils, and T cells. These interactions prevent macrophage-mediated clearance of healthy CD47-expressing cells and promote immune cell transmigration across the vascular endothelium. CD47 associates in cis with Fas on T cells and enhances Fas-mediated apoptosis; its ligation promotes T cell anergy and dampens Th1 immune responses. CD47 also associates in cis with several Integrins?which can positively or negatively modulate Integrin-mediated function. CD47 binding by Thrombospondin-1 inhibits the angiogenic and vasorelaxant effects of nitric oxide. On dendritic cells and myeloma cells, CD47 ligation by TSP-1 induces giant cell formation and osteoclast differentiation.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 2 of 2.

Publications using DY4670-05	Applications	Species
M Yao, J Sturdivant, A Ebrahimi, S Ganguly, T Elbayoumi Novel Pharmaceutical Strategy for Selective Abrogation of TSP1-Induced Vascular Dysfunction by Decoy Recombinant CD47 Soluble Receptor in Prophylaxis and Treatment Models Biomedicines, 2021-06-03;9(6):. 2021-06-03 [PMID: 34205047] (Mouse)		Mouse
A rapid, automated surface protein profiling of single circulating exosomes in human blood Sci Rep, 2016-11-07;6(0):36502. 2016-11-07 [PMID: 27819324] (Human)		Human

Array DY4670-05

• CD47 Antibodies
• CD47 Lysates
• CD47 Proteins
• CD47 Proteins and Enzymes
• CD47 ELISA