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HuC Antibody

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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HuC Antibody Summary

Description
Relevant Entrez Gene Numbers: NM_001420.3;NM_032281.2
Immunogen
Synthetic peptide, amino acids 20-46 of HuC.
Marker
Neuronal & Glial Markers
Specificity
Recognizes HuC. The molecular weight of the protein is 38,862 Daltons.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ELAVL3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 1:200-1:1000
  • Western Blot 1:200-1:1000
Theoretical MW
38.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
50% saturated ammonium sulfate and PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

Relevant Entrez Gene Numbers: NM_001420.3;NM_032281.2

Alternate Names for HuC Antibody

  • DKFZp547J036
  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
  • ELAV-like protein 3
  • Hu antigen C
  • Hu-antigen C
  • HuC
  • HUCL
  • HUCParaneoplastic cerebellar degeneration-associated antigen
  • MGC20653
  • PLE21Paraneoplastic limbic encephalitis antigen 21

Background

HuC is a member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ELAVL3
Uniprot