Name: G9a/EHMT2 Antibody (A8620A) [Unconjugated]
Brand: Novus Biologicals
SKU: PP-A8620A-00
Price: 469 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, MuSpecies Glossary
Applications	WB, IHC, IP, ELISA
Clone	A8620A
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Suitable Sample Type	23005

Immunogen	Recombinant mouse G9a/EHMT2 aa 15-114
Specificity	This antibody specifically recognizes mouse G9a and cross-reacts with human G9a. Not yet tested in other species.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Mouse
Gene	EHMT2
Purity Statement	Protein A or G purified from ascites
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	This antibody is stable for greater than six months when held at -20° C in a manual defrost freezer or at -70°C. Upon thawing, the antibody can be stored at 2° - 8° C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Buffer	A liquid formulation in physiologic saline with 0.1% NaN₃.
Preservative	0.1% Sodium Azide

Publications using PP-A8620A-00	Applications	Species
Huang, Z;Cui, W;Ratnayake, I;Tawil, R;Pfeifer, GP; SMCHD1 maintains heterochromatin and genome compartments in human myoblasts bioRxiv : the preprint server for biology 2024-07-10 [PMID: 39026812] (Western Blot, Human)	Western Blot	Human
Hsu, CM;Chang, KC;Chuang, TM;Chu, ML;Lin, PW;Liu, HS;Kao, SY;Liu, YC;Huang, CT;Wang, MH;Yeh, TJ;Gau, YC;Du, JS;Wang, HC;Cho, SF;Hsiao, CE;Tsai, Y;Hsiao, SY;Hung, LC;Yen, CH;Hsiao, HH; High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach Cancers 2023-08-17 [PMID: 37627178] (IHC, Human)	IHC	Human
Able, AA;Richard, AJ;Stephens, JM; TNF? Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1) Biology 2023-04-30 [PMID: 37237488] (Western Blot, Mouse)	Western Blot	Mouse
LT Yuan, WJ Lee, YC Yang, BR Chen, CY Yang, MW Chen, JQ Chen, M Hsiao, MH Chien, KT Hua Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122 Cancers, 2021-05-14;13(10):. 2021-05-14 [PMID: 34069116] (IHC, Human)	IHC	Human
T Nakatsuka, K Tateishi, H Kato, H Fujiwara, K Yamamoto, Y Kudo, H Nakagawa, Y Tanaka, H Ijichi, T Ikenoue, T Ishizawa, K Hasegawa, M Tachibana, Y Shinkai, K Koike Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis Cell Death & Disease, 2021-01-19;12(1):99. 2021-01-19 [PMID: 33468997] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Tian H, Billings T, Walker M et al. EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis Mol Biol Cell 2020-11-11 [PMID: 33175657]
Z Li, X Jiao, G Di Sante, A Ertel, MC Casimiro, M Wang, S Katiyar, X Ju, DV Klopfenste, A Tozeren, W Dampier, I Chepelev, A Jeltsch, RG Pestell Cyclin D1 integrates G9a-mediated histone methylation Oncogene, 2019-02-04;0(0):. 2019-02-04 [PMID: 30718920] (ChIP, ICC, Western Blot, Mouse)	ChIP, ICC, Western Blot	Mouse
L Li, W Liu, H Wang, Q Yang, L Zhang, F Jin, Y Jin Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions Cell Death Dis, 2018-05-01;9(5):480. 2018-05-01 [PMID: 29691366] (Western Blot, Human)	Western Blot	Human
RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival Oncotarget, 2017-07-07;8(37):62081-62098. 2017-07-07 [PMID: 28977928] (IHC, Human)	IHC	Human
Ozge Gursoy-Yuzugullu, Chelsea Carman, Rodolfo Bortolozo Serafim, Marios Myronakis, Valeria Valente, Brendan D. Price Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity Oncotarget 2017-04-11 [PMID: 28445939]
CW Liu, KT Hua, KC Li, HF Kao, RL Hong, JY Ko, M Hsiao, ML Kuo, CT Tan Histone methyltransferase G9a drives chemotherapy resistance by regulating the glutamate-cysteine ligase catalytic subunit in head and neck squamous cell carcinoma Mol. Cancer Ther, 2017-03-06;0(0):. 2017-03-06 [PMID: 28265008] (IHC-P, Human)	IHC-P	Human
Pei Han, Wei Li, Jin Yang, Ching Shang, Chiou-Hong Lin, Wei Cheng et al. Epigenetic response to environmental stress: Assembly of BRG1–G9a/GLP–DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts☆,☆☆ Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2016-07-01 [PMID: 26952936]
Ghislain Auclair, Julie Borgel, Lionel A. Sanz, Judith Vallet, Sylvain Guibert, Michael Dumas et al. EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos Genome Research 2016-02-01 [PMID: 26576615]
Li , Kai-Chun, Hua , Kuo-Tai, Lin , Yi-Shen, Su , Chia-Yi, Ko , Jenq-Yuh, Hsiao , Michael, Kuo , Min-Lian, Tan , Ching-Ti Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma. Mol Cancer, 2014-07-15;13(0):172. 2014-07-15 [PMID: 25027955] (IHC, Human)	IHC	Human
Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill T, Jin J, Hebert J, Sauvageau G, Humphries R, Rossi F The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev, 2014-02-15;28(4):317-27. 2014-02-15 [PMID: 24532712] (Western Blot, Human)	Western Blot	Human
Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res., 2010-10-12;70(20):7830-40. 2010-10-12 [PMID: 20940408] (IHC-P, Human)	IHC-P	Human
Dong K, Maksakova I, Mohn F, Leung D, Appanah R, Lee S, Yang H, Lam L, Mager D, Schubeler D, Tachibana M, Shinkai Y, Lorincz M DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J, 2008-09-25;27(20):2691-701. 2008-09-25 [PMID: 18818693] (Western Blot, Mouse)	Western Blot	Mouse
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G9a/EHMT2 Antibody (A8620A) [Unconjugated]

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