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HCN4 Antibody (880904)

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HCN4 was detected in immersion fixed BG01V human embryonic stem cells differentiated to cardiac cells using Mouse Anti-Human HCN4 Monoclonal Antibody (Catalog # MAB8138) at 10 µg/mL for 3 hours at room temperature. ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clone
880904
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price
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HCN4 Antibody (880904) Summary

Immunogen
E. coli-derived recombinant human HCN4
Lys1084-Leu1203
Accession # Q9Y3Q4
Specificity
Detects human HCN4 in ELISA
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
HCN4
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry 8-25 ug/mL
Publications
Read Publication using MAB8138.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HCN4 Antibody (880904)

  • HCN4
  • hyperpolarization activated cyclic nucleotide-gated cation channel 4
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4
  • potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
  • SSS2

Background

HCN4 (hyperpolarization-activated cyclic nucleotide-gated channel 4) is a 120-160 kDa, 1203 amino acid (aa) multipass plasma membrane protein that is a member of the HCN family of potassium channel proteins. It is mainly expressed in cardiac myocytes, thalamus and testis. HCN4 is important for pacemaker function in the heart, and rhythmic activity in the thalamus. Specific mutations can cause Sick Sinus Syndrome 2 (SSS2), a cardiac sinus node malfunction, or Brugada syndrome 8 (BRGDA8), a tachyarrhythmia syndrome. Within aa 1084-1203, human HCN4 shares 92% and 93% aa sequence identity with mouse and rat HCN4, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for HCN4 Antibody (MAB8138)(1)

Reviews for HCN4 Antibody (MAB8138) (0)

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FAQs for HCN4 Antibody (MAB8138) (0)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol HCN4
Uniprot