Name: Granzyme B Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF1865
Price: 499 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	WB, IHC, IP, B/N, ELISA(Cap), ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF1865

Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse Granzyme B Lys17-Ser247 Accession # P04187
Specificity	Detects mouse Granzyme B in ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	GZMB
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Granzyme B Antibody [Unconjugated]

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Publications for Granzyme B Antibody (AF1865)(25)

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Bioinformatics

Publications using AF1865	Applications	Species
Malyshkina, A;Bayer, W;Podschwadt, P;Otto, L;Karakoese, Z;Sutter, K;Bruderek, K;Wang, B;Lavender, KJ;Santiago, ML;Leipe, PM;Elsner, C;Esser, S;Brandau, S;Gunzer, M;Dittmer, U; Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles PLoS pathogens 2023-10-01 [PMID: 37883584] (IHC, Mouse)	IHC	Mouse
Jimeng Xue, Liling Xu, Hua Zhong, Mingxin Bai, Xin Li, Ranran Yao et al. Impaired regulatory function of granzyme B-producing B cells against T cell inflammatory responses in lupus mice Lupus Science & Medicine 7/27/2023 [PMID: 37500293]
Shingo Umemoto, Rika Nakahashi-Ouchida, Yoshikazu Yuki, Shiho Kurokawa, Tomonori Machita, Yohei Uchida et al. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents npj Vaccines 7/24/2023 [PMID: 37488116]
TS Napier, CL Hunter, PN Song, BM Larimer, AG Sorace Preclinical PET Imaging of Granzyme B Shows Promotion of Immunological Response Following Combination Paclitaxel and Immune Checkpoint Inhibition in Triple Negative Breast Cancer Pharmaceutics, 2022-02-18;14(2):. 2022-02-18 [PMID: 35214172] (IHC, Mouse)	IHC	Mouse
M Deschuyter, DY Leger, A Verboom, A Chaunavel, A Maftah, JM Petit ST3GAL2 knock-down decreases tumoral character of colorectal cancer cells in vitro and in vivo American journal of cancer research, 2022-01-15;12(1):280-302. 2022-01-15 [PMID: 35141018] (Western Blot, Human)	Western Blot	Human
Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu et al. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation iScience 9/24/2021 [PMID: 34568799]
Shiuh-Rong Ho, Yu-Cheng Lee, Michael M. Ittmann, Fang-Tsyr Lin, Keith Syson Chan, Weei-Chin Lin RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis Cancer Letters 11/1/2021 [PMID: 34400221]
Y Koda, T Teratani, PS Chu, Y Hagihara, Y Mikami, Y Harada, H Tsujikawa, K Miyamoto, T Suzuki, N Taniki, T Sujino, M Sakamoto, T Kanai, N Nakamoto CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells Nature Communications, 2021-07-22;12(1):4474. 2021-07-22 [PMID: 34294714] (IHC, Mouse)	IHC	Mouse
Lingfei Jia, Yilun Wang, Cun‐Yu Wang circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation Advanced Science 7/1/2021 [PMID: 34258151]
Manish Muhuri, Wei Zhan, Yukiko Maeda, Jia Li, Anoushka Lotun, Jennifer Chen et al. Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction Frontiers in Immunology 4/28/2021 [PMID: 33995418]
Wuchang Zhang, Wei Liu, Lingfei Jia, Demeng Chen, Insoon Chang, Michael Lake et al. Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress Molecular Cell 5/1/2021 [PMID: 33743195]
Pires, A, Greenshields-Watson, A Et al. Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection. Cancer Immunol Res 12/1/2020 [PMID: 33023965]
Young Jun Shim, Raneem Khedraki, Jayeeta Dhar, Ran Fan, Nina Dvorina, Anna Valujskikh et al. Early T cell infiltration is modulated by programed cell death-1 protein and its ligand (PD-1/PD-L1) interactions in murine kidney transplants. Kidney International 10/1/2020 [PMID: 32763116]
L Jia, W Zhang, CY Wang BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse Cell Stem Cell, 2020-07-21;27(2):238-253.e6. 7/21/2020 [PMID: 32697949]
V Abadie, SM Kim, T Lejeune, BA Palanski, JD Ernest, O Tastet, J Voisine, V Discepolo, EV Marietta, MBF Hawash, C Ciszewski, R Bouziat, K Panigrahi, I Horwath, MA Zurenski, I Lawrence, A Dumaine, V Yotova, JC Grenier, JA Murray, C Khosla, LB Barreiro, B Jabri IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease Nature, 2020-02-12;0(0):. 2020-02-12 [PMID: 32051586] (IHC, Mouse)	IHC	Mouse
Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang et al. The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation Cell Communication and Signaling 12/27/2019 [PMID: 31881947]
LC Chan, CW Li, W Xia, JM Hsu, HH Lee, JH Cha, HL Wang, WH Yang, EY Yen, WC Chang, Z Zha, SO Lim, YJ Lai, C Liu, J Liu, Q Dong, Y Yang, L Sun, Y Wei, L Nie, JL Hsu, H Li, Q Ye, MM Hassan, HM Amin, AO Kaseb, X Lin, SC Wang, MC Hung IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion J. Clin. Invest., 2019-07-15;130(0):. 2019-07-15 [PMID: 31305264] (IHC-Fr, Mouse)	IHC-Fr	Mouse
C Pantelidou, O Sonzogni, M de Oliveir, AK Mehta, A Kothari, D Wang, T Visal, MK Li, J Pinto, JA Castrillon, EM Cheney, P Bouwman, J Jonkers, S Rottenberg, JL Guerriero, GM Wulf, GI Shapiro PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer Cancer Discov, 2019-04-23;0(0):. 2019-04-23 [PMID: 31015319] (IHC, Mouse)	IHC	Mouse
Cha JH, Yang WH, Xia W et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 Mol. Cell 8/16/2018 [PMID: 30118680]
WH Yang, JH Cha, W Xia, HH Lee, LC Chan, YN Wang, JL Hsu, G Ren, MC Hung Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression Cancer Res., 2018-05-22;0(0):. 5/22/2018 [PMID: 29789418]
MA Farrag, HM Amer, P Öhlschläge, ME Hamad, FN Almajhdi Novel Recombinant DNA Vaccine Candidates for Human Respiratory Syncytial Virus: Preclinical Evaluation of Immunogenicity and Protection Efficiency Hum Vaccin Immunother, 2017-03-08;0(0):0. 2017-03-08 [PMID: 28272978] (Functional Assay, Mouse)	Functional Assay	Mouse
Fahad N. Almajhdi, Tilo Senger, Haitham M. Amer, Lutz Gissmann, Peter Öhlschläger Design of a Highly Effective Therapeutic HPV16 E6/E7-Specific DNA Vaccine: Optimization by Different Ways of Sequence Rearrangements (Shuffling) PLoS ONE 11/25/2014 [PMID: 25422946]
Whitehead M, Ohlschlager P, Almajhdi F, Alloza L, Marzabal P, Meyers A, Hitzeroth I, Rybicki E Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice. BMC Cancer, 2014-05-24;14(0):367. 2014-05-24 [PMID: 24885328] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Duncan F, Silva K, Johnson C, King B, Szatkiewicz J, Kamdar S, Ong D, Napoli J, Wang J, King L, Whiting D, McElwee K, Sundberg J, Everts H Endogenous retinoids in the pathogenesis of alopecia areata. J Invest Dermatol, 2012-09-27;133(2):334-43. 2012-09-27 [PMID: 23014334] (IHC, Mouse)	IHC	Mouse
Zhang M, Park SM, Wang Y, Shah R, Liu N, Murmann AE, Wang CR, Peter ME, Ashton-Rickardt PG Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Immunity, 2006-04-01;24(4):451-61. 2006-04-01 [PMID: 16618603] (ICC, Mouse)	ICC	Mouse
Show All 25 Publications. Collapse Publications.

Catalog# & Formulation	Size	Price
Carrier Free AF1865-SP

Gene Symbol	GZMB
Uniprot	P04187()