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GLP-1R Antibody

Images

 
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human ovary carcinoma after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human pancreas
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human adrenal, pheochromocytoma, after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human lung, small cell carcinoma, after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human pancreas, islet of Langerhans, after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of formalin-fixed, paraffin-embedded human skin melanoma after heat-induced antigen retrieval.
Immunohistochemistry: GLP-1R Antibody [NBP3-14335] - Immunohistochemistry of adrenal

Product Details

Summary
Reactivity Hu, Mu, Bv, Ha, Pm, RbSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

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GLP-1R Antibody Summary

Description
Product can be stored undiluted at 4C for up to 1 month.
Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human GLP-1R.
Epitope
N-Terminus
Specificity
Human GLP-1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Mouse (94%), Bovine (94%), Rabbit (94%), Primate (100%), Hamster (94%). Backed by our 100% Guarantee.
Clonality
Polyclonal
Host
Rabbit
Gene
GLP1R
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
.

Reactivity Notes

Expected reactivity based on percent sequence identity: Rat, Canine, Bat (88%)

Packaging, Storage & Formulations

Storage
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GLP-1R Antibody

  • GLP-1 receptor
  • GLP1R
  • GLP-1R
  • GLP-1-R
  • glucagon-like peptide 1 receptor
  • MGC138331

Background

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for GLP-1R Antibody (NBP3-14335) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GLP1R