GCN2 Antibody

GCN2 is a kinase that phosphorylates the alpha subunit of EIF2. GCN2 functions as a sensor of amino acid deficiency and modulates protein metabolism in response to cellular stress. GCN2 has also been reported to function in the regulation of lipid metabolism during amino acid deprivation. Alternate names for GCN2 include eukaryotic translation initiation factor 2-alpha kinase 4, GCN2-like protein, EIF2AK4, and KIAA1338.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-1593	Applications	Species
Rahmani M, Davis EM, Crabtree TR et al. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol. 2007-08-01 [PMID: 17548474] Details: WB: Fig 3A, U937 human leukemia cells treated with sorafenib. Sorafenib is a multikinase inhibitor that induces apoptosis in human leukemia and other malignant cells. The authors show a decline in ATF6 (90 kDa band) expression in sorafenib-treated cells.

Array NB100-1593

• GCN2 Antibodies
• GCN2 Proteins