Galectin-3 Antibody [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The galectins constitute a large family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. At least 14 mammalian galectins, which share structural similarities in their carbohydrate recognition domains (CRD), have been identified. The galectins have been classified into the prototype galectins (-1, -2, -5, -7, -10, -11, -13, -14), which contain one CRD and exist either as a monomer or a noncovalent homodimer; the chimera galectins (Galectin-3) containing one CRD linked to a nonlectin domain; and the tandem-repeat galectins (-4, -6, -8, -9, -12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified non-classical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell-surface glycoproteins.

Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is a chimera galectin that has a tendency to dimerize. Besides the soluble protein, alternatively spliced forms of chicken Galectin-3 containing a transmembrane-spanning domain and a leucine zipper motif have been reported. Galectin-3 is expressed in tumor cells, macrophages, activated T cells, osteoclasts, epithelial cells, and fibroblasts. It binds various matrix glycoproteins including laminin, fibronectin, LAMPS, 90K/Mac-2BP, MP20, and CEA. Galectin-3 promotes cell growth and proliferation for many cell types. Galectin-3 acts intracellularly to prevent apoptosis. Depending on the cell types, Galectin-3 exhibits pro- or anti-adhesive properties. Galectin-3 has pro-inflammatory activities in vitro and in vivo. It induces pro-inflammatory and inhibits Th2 type cytokine production. Galectin-3 chemoattracts monocytes and macrophages. It activates and degranulates basophils and mast cells. Elevated circulating levels of Galectin-3 has been show to correlate with the malignant potential of several types of cancer, suggesting that Galectin-3 is also involved in tumor growth and metastasis. Human and mouse Galectin-3 shares approximately 80% amino acid sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Immunocytochemistry.

Showing Publications 1 - 4 of 4.

Publications using IC1154G	Applications	Species
Migliano, SM;Schultz, SW;Wenzel, EM;Takáts, S;Liu, D;Mørk, S;Tan, KW;Rusten, TE;Raiborg, C;Stenmark, H; Removal of hypersignaling endosomes by simaphagy Autophagy 2023-10-16 [PMID: 37840274] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Maja Radulovic, Eva Maria Wenzel, Sania Gilani, Lya KK Holland, Alf Håkon Lystad, Santosh Phuyal et al. Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair The EMBO Journal 12/15/2022 [PMID: 36408828]
Maja Radulovic, Kay O Schink, Eva M Wenzel, Viola Nähse, Antonino Bongiovanni, Frank Lafont et al. ESCRT ‐mediated lysosome repair precedes lysophagy and promotes cell survival The EMBO Journal 11/2/2018 [PMID: 30314966]
SM Richardson, FE Ludwinski, KK Gnanalingh, RA Atkinson, AJ Freemont, JA Hoyland Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration Sci Rep, 2017-05-04;7(1):1501. 2017-05-04 [PMID: 28473691] (Flow Cytometry, Human)	Flow Cytometry	Human

Array IC1154G

• Galectin-3 Antibodies
• Galectin-3 Antibody Pair
• Galectin-3 ELISA Kits
• Galectin-3 Lysate
• Galectin-3 Proteins
• Galectin-3 ELISAs
• Galectin-3 Proteins and Enzymes